Table 2.
Association of BMI change after COPD diagnosis for all-cause mortality and severe exacerbation
| Number of incidence (rate per 100 person-year) |
Adjusteda) HR (95% CI) | |
|---|---|---|
| All-cause mortality (N = 116,463) | ||
| Over 5% decrease | 1,934 (3.5) | 1.70 (1.61, 1.79) |
| Maintenance | 4,981 (1.6) | Reference |
| Over 5% increase | 1,497 (1.9) | 1.13 (1.07, 1.20) |
| Severe exacerbation (N = 108,067)b) | ||
| Over 5% decrease | 2,646 (6.0) | 1.30 (1.24, 1.35) |
| Maintenance | 10,804 (4.1) | Reference |
| Over 5% increase | 3,115 (4.8) | 1.12 (1.07, 1.16) |
a) Adjusted for age, sex, smoking status, drinking status, residential area, income, CCI, regular MVPA, previous severe exacerbation within a year before Exam 2 (baseline), medication use (ICS, LABA, or LAMA) within 1 year before Exam 2 (baseline), pulmonary TB, bronchiectasis, and pneumonia
b) Patients without a history of previous severe exacerbation between COPD diagnosis and Exam 2 (baseline) were included
BMI, body mass index; COPD, chronic obstructive pulmonary disease; CCI, Charlson Comorbidity Index; CI, confidence interval; HR, hazard ratio; MVPA, moderate-to-vigorous physical activity; ICS, inhaled corticosteroids; LABA, long-acting beta-2 agonist; LAMA, long-acting muscarinic agonist; TB, tuberculosis