Table 3.
Association of BMI change after COPD diagnosis for all-cause mortality according to BMI before COPD diagnosis
| Over 5% decrease Adjusteda) HR (95% CI) |
Maintenance | Over 5% increase Adjusteda) HR (95% CI) |
p for interaction | |
|---|---|---|---|---|
| BMI before COPD diagnosis | 0.05 | |||
| Underweight (N = 5,545) | 1.77 (1.50, 2.09) | Reference | 0.87 (0.75, 1.02) | |
| Normal (N = 41,286) | 1.73 (1.60, 1.88) | Reference | 1.03 (0.95, 1.12) | |
| Overweight (N = 28,470) | 1.75 (1.56, 1.97) | Reference | 0.98 (0.85, 1.13) | |
| Obese (N = 41,162) | 1.62 (1.45, 1.80) | Reference | 1.18 (1.03, 1.36) |
a) Adjusted for age, sex, smoking status, drinking status, residential area, income, CCI, regular MVPA, previous severe exacerbation within a year before Exam 2 (baseline), medication use (ICS, LABA, or LAMA) within 1 year before Exam 2 (baseline), pulmonary TB, bronchiectasis, and pneumonia
BMI, body mass index; COPD, chronic obstructive pulmonary disease; CCI, Charlson Comorbidity Index; CI, confidence interval; HR, hazard ratio; MVPA, moderate-to-vigorous physical activity; ICS, inhaled corticosteroids; LABA, long-acting beta-2 agonist; LAMA, long-acting muscarinic agonist; TB, tuberculosis