Table 2.
Risk of incident AF according to DM duration and physical activity
| DM Duration | METs-Min/week | N | AF | IR per 1000 PY |
Model 5 Composite | p-value | Model 5 Subgroup | p-value | p-for-interaction |
|---|---|---|---|---|---|---|---|---|---|
| Total | 0 | 544,927 | 12,904 | 6.20 | 1 (Reference) | < 0.001 | |||
| < 500 | 650,353 | 11,858 | 4.74 | 0.93 (0.90–0.95) | |||||
| 500–999 | 648,499 | 12,104 | 4.84 | 0.92 (0.90–0.95) | |||||
| 1000–1499 | 284,775 | 4625 | 4.18 | 0.87 (0.84–0.90) | |||||
| ≥ 1500 | 263,932 | 5183 | 5.07 | 0.90 (0.87–0.93) | |||||
| New onset | 0 | 151,684 | 2466 | 4.28 | 1 (Reference) | < 0.001 | 1 (Reference) | 0.001 | 0.002 |
| < 500 | 199,056 | 2300 | 3.03 | 0.90 (0.85–0.95) | 0.90 (0.85–0.95) | ||||
| 500–999 | 195,121 | 2440 | 3.28 | 0.94 (0.89–0.99) | 0.94 (0.89–0.99) | ||||
| 1000–1499 | 88,335 | 1004 | 2.97 | 0.88 (0.82–0.95) | 0.88 (0.82–0.95) | ||||
| ≥ 1500 | 70,536 | 1100 | 4.07 | 1.01 (0.95–1.09) | 1.01 (0.95–1.09) | ||||
| < 5 years | 0 | 150,864 | 3092 | 5.26 | 0.97 (0.916–1.02) | 1 (Reference) | 0.009 | ||
| < 500 | 180,403 | 2897 | 4.11 | 0.90 (0.85–0.95) | 0.93 (0.89–0.98) | ||||
| 500–999 | 175,075 | 2882 | 4.21 | 0.90 (0.85–0.95) | 0.93 (0.88–0.98) | ||||
| 1000–1499 | 75,923 | 1135 | 3.80 | 0.88 (0.82–0.94) | 0.91 (0.85–0.97) | ||||
| ≥ 1500 | 67,546 | 1146 | 4.33 | 0.88 (0.82–0.94) | 0.91 (0.85–0.97) | ||||
| 5–9 years | 0 | 10,769 | 2814 | 6.78 | 1.01 (0.95–1.062 | 1 (Reference) | < 0.001 | ||
| < 500 | 124,166 | 2632 | 5.46 | 0.95 (0.90–1.00) | 0.95 (0.90–1.00) | ||||
| 500–999 | 125,148 | 2675 | 5.49 | 0.95 (0.89–1.00) | 0.94 (0.89–0.99) | ||||
| 1000–1499 | 54,732 | 944 | 4.40 | 0.83 (0.77–0.90) | 0.83 (0.77–0.89) | ||||
| ≥ 1500 | 53,132 | 1093 | 5.26 | 0.88 (0.82–0.95) | 0.88 (0.82–0.94) | ||||
| ≥ 10 years | 0 | 134,687 | 4532 | 9.00 | 1.02 (0.97–1.07) | 1 (Reference) | < 0.001 | ||
| < 500 | 146,728 | 4029 | 7.22 | 0.94 (0.89–0.92) | 0.92 (0.89–0.96) | ||||
| 500–999 | 153,155 | 4107 | 7.02 | 0.91 (0.87–0.96) | 0.90 (0.86–0.94) | ||||
| 1000–1499 | 65,785 | 1542 | 6.08 | 0.88 (0.82–0.93) | 0.86 (0.81–0.91) | ||||
| ≥ 1500 | 72,718 | 1844 | 6.60 | 0.87 (0.81–0.92) | 0.85 (0.81–0.90) |
Model 5: adjusted for age, sex, comorbidities (hypertension, dyslipidemia, chronic kidney disease), anti-hyperglycemic agent usage (more than three drug prescription, insulin), BMI, fasting glucose, low income, social behavior (smoking, alcohol), heart failure, prior myocardial infarction, prior stroke, peripheral artery disease, estimated glomerular filtration rate and proteinuria
Abbreviation AF, atrial fibrillation; DM, diabetes mellitus; IR, incidence rate; PY, person-year