. 2024 Mar 31;24:406. doi: 10.1186/s12903-024-04182-0

Table 3.

Evaluation of GRADE pro-GDT

Certainty assessment	№ of patients	Effect	Certainty	Importance
13	Observational studies	not serious	not serious	not serious	not serious	all plausible residual confounding would suggest spurious effect, while no effect was observed dose response gradient	495/891 (55.6%)	396/891 (44.4%)	HR 1.34 (1.25 to 1.44)	⨁⨁⨁⨁¹ High	CRITICAL

Certainty assessment

№ of patients

Effect

Certainty

Importance

№ of studies

Study design

Risk of bias

Inconsistency

Indirectness

Imprecision

Other considerations

Intervention

Control

Relative
(95% CI)

Observational studies

not serious

all plausible residual confounding would suggest spurious effect, while no effect was observed

dose response gradient

495/891 (55.6%)

396/891 (44.4%)

HR 1.34

(1.25 to 1.44)

⨁⨁⨁⨁¹

High

CRITICAL

¹Certainty: ⨁⨁⨁⨁ High

The HR of OS-1.34 (1.25 to 1.44) indicated higher levels of different miRNAs expressions in TSCC patients, demonstrating great statistical significance in prognosis of TSCC patients