Table 3.
The origins and targets of the main soluble mediators in pulmonary hypertension
| Produced by | Affects | |
|---|---|---|
| IL-1 | Fibroblast, macrophage, neutrophil, T cell, VSMCs | VSMCs, macrophage |
| IL-6 | Fibroblast, VSMCs, Th1 cell, macrophage | Macrophage, Th1 cell, Th2 cell |
| IL-8 | VSMC, macrophage, VECs | Neutrophil |
| IL-10 | Th2 cell, B-cell | Macrophage, Th1 cell, VSMCs |
| MIF | Fibroblast, macrophage, VECs | VSMCs, VECs |
| CCL2 | Fibroblast, VECs, VSMCs | Macrophage |
| CCL5 | Fibroblast, VECs | Macrophage |
| CX3CL1 | Macrophage, VECs | Macrophage, VSMCs |
| CXCL12 | Fibroblast, VECs | Macrophage |
Abbreviations: IL, Interleukin; VSMCs, vascular smooth muscle cells; VECs, vascular endothelial cells; MIF, migration inhibitory factor