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. 2024 Mar 18;18:1356674. doi: 10.3389/fnhum.2024.1356674

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Copyright © 2024 Flynn, Bouras, Migovich, Clarin and Gao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Schematic representation of PFC microcircuitry. Diagram depicting the microcircuitry of the pyramidal neuron (PN) with each of the three interneuron (IN) subtypes. Parvalbumin-expressing INs (PV) inhibit PNs that are not tuned to the relevant receptive field. Somatostatin-expressing INs (SST) inhibit PNs, and their activity is associated with the delay period of working memory (WM) tasks. Vasoactive intestinal peptide-expressing INs (VIP) inhibit PV and SST INs, thus disinhibiting PNs.