Table 2.
The regulatory effects of rs6430538 variant C allele on TMEM163 in both AD and neuropathologically normal individuals.
| Datasets | Beta | P value | Brain tissue | Number |
|---|---|---|---|---|
| Mayo | 0.0049 | 8.14E-02 | Cerebellum (AD) | 186 |
| −0.0072 | 4.52E-03 | Cerebellum (non-AD) | 170 | |
| 0.0039 | 3.47E-01 | Temporal cortex (AD) | 191 | |
| 0.0043 | 2.87E-01 | Temporal cortex (non-AD) | 181 | |
| ROSMAP | 0.325 | 1.31E-13 | DLPFC (AD) | 494 |
| GTEx | −0.27 | 1.0E-02 | Brain—Amygdala (normal) | 88 |
| −0.17 | 1.4E-02 | Brain—Anterior cingulate cortex (normal) | 109 | |
| −0.31 | 3.2E-05 | Brain—Caudate (normal) | 144 | |
| −0.11 | 1.4E-02 | Brain—Cerebellar Hemisphere (normal) | 125 | |
| −0.14 | 8.1E-03 | Brain—Cerebellum (normal) | 154 | |
| −0.25 | 3.9E-06 | Brain—Cortex (normal) | 136 | |
| −0.16 | 1.5E-03 | Brain—Frontal Cortex (normal) | 118 | |
| 0.043 | 4.4E-01 | Brain—Hippocampus (normal) | 111 | |
| −0.19 | 2.9E-03 | Brain—Hypothalamus (normal) | 108 | |
| −0.22 | 1.4E-03 | Brain—Nucleus accumbens (normal) | 130 | |
| −0.27 | 5.8E-04 | Brain—Putamen (normal) | 111 | |
| 0.047 | 5.9E-01 | Brain—Spinal cord (normal) | 83 | |
| −0.0023 | 9.8E-01 | Brain—Substantia nigra (normal) | 80 |
Beta is the regression coefficient based on the effect allele. Beta > 0 and beta < 0 mean that this effect allele could increase and reduce gene expression, respectively. The statistically significant association is defined to be P < 0.05/18 = 2.78E-03.