Table 4.
6MP-induced toxicity during childhood ALL maintenance therapy (92 patients) N (%).
| AE | All Grades | Grade 1 | Grade 2 | Grade 3 | Grade 4 |
|---|---|---|---|---|---|
| Leukopenia | 74 (80.4) | 10 (10.9) | 21 (22.8) | 36 (39.1) | 7 (7.6) |
| Anemia | 45 (48.9) | 30 (32) | 10 (10.9) | 5 (5.4) | 0 (0) |
| Thrombocytopenia | 25 (27.1) | 11 (12) | 8 (8.7) | 5 (5.4) | 1 (1.1) |
| Elevated AST/ALT | 42 (45.6) | 15 (16.3) | 15 (16.3) | 11 (11.9) | 1 (1.1) |
| Vomiting/nausea | 4 (4.3) | 1 (1.1) | 3 (3.3) | 0 (0) | 0 (0) |
| Diarrhea | 2 (2.2) | 0 (0) | 2 (2.2) | 0 (0) | 0 (0) |
| Alopecia | 6 (6.6) | 3 (3.3) | 3 (3.3) | 0 (0) | 0 (0) |
| Pneumonia | 1 (1.1) | 0 (0) | 1 (1.1) | 0 (0) | 0 (0) |
| Rash | 2 (2.2) | 1 (1.1) | 1 (1.1) | 0 (0) | 0 (0) |
| AEs any grade | 84 (91.3) | NA | NA | NA | NA |
| AEs G3/4 | 46 (50) | NA | NA | NA | NA |
| Therapy interruption | 27 (29.3) | NA | NA | NA | NA |
AEs, Adverse events; ALL, acute lymphoblastic leukemia; ALT, alanine aminotransferase; AST, aspartate aminotransferase; MP, mercaptopurine; NA, not applicable.