Table 2.
Performance Characteristics of KFRE-2 Thresholds
| Derivation Cohort | 10% | 20% | 30% | 40% | 50% | 60% | 70% | 80% | 90% |
| Sensitivity | 90% | 78% | 76% | 62% | 52% | 39% | 26% | 16% | 5% |
| Specificity | 48% | 66% | 80% | 88% | 92% | 95% | 97% | 99% | 100% |
| PPV | 30% | 36% | 48% | 56% | 63% | 68% | 72% | 74% | 80% |
| NPV | 95% | 93% | 93% | 90% | 89% | 86% | 84% | 83% | 81% |
| AUC (95% CI) | 0.83 (0.78-0.88) | ||||||||
| Validation Cohort | 10% | 20% | 30% | 40% | 50% | 60% | 70% | 80% | 90% |
| Sensitivity | 97% | 83% | 74% | 64% | 55% | 47% | 37% | 26% | 12% |
| Specificity | 10% | 48% | 67% | 81% | 89% | 93% | 97% | 98% | 100% |
| PPV | 32% | 41% | 49% | 59% | 68% | 75% | 83% | 87% | 91% |
| NPV | 87% | 86% | 85% | 84% | 82% | 80% | 78% | 75% | 72% |
| AUC (95% CI) | 0.78 (0.73-0.82) | ||||||||
Abbreviations: AUC, area under the curve; CI, confidence interval; KFRE, Kidney Failure Risk Equation; NPV, negative predictive value; PPV, positive predictive value.