Table 2.
Treatment exposure | Olaparib alone (n = 23) | Olaparib plus durvalumab (n = 22) |
---|---|---|
Olaparib | ||
Median (range) of olaparib cycles | 5 (2–19) | 5.5 (1–24) |
Patients with olaparib dose interruption | 18 (78) | 18 (82) |
Due to AE | 9 (39) | 10 (45) |
Lasting ≥3 days | 8 (35) | 9 (41) |
Lasting ≥14 days | 3 (13) | 1 (5) |
Patients with olaparib dose reductiona | 4 (17) | 2 (9) |
Due to AE | 3 (13) | 2 (9) |
Due to physician decision | 2 (9) | 0 |
Patients with olaparib permanently discontinued | 20 (87) | 16 (73) |
Olaparib treatment ongoing | 3 (13) | 6 (27) |
Durvalumab | ||
Median (range) of durvalumab cycles | — | 4 (1–24) |
Patients with ≥1 durvalumab cycle omitted | — | 2 (9) |
Patients with durvalumab permanently discontinued | — | 16 (73) |
Durvalumab treatment ongoing | — | 6 (27) |
Note: Data are n (%) unless otherwise specified.
Abbreviation: AE, adverse event.
aMore than one reason possible.