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. 2024 Jan 18;30(7):1240–1247. doi: 10.1158/1078-0432.CCR-23-2513

Table 2.

Treatment exposure.

Treatment exposure Olaparib alone (n = 23) Olaparib plus durvalumab (n = 22)
Olaparib
Median (range) of olaparib cycles 5 (2–19) 5.5 (1–24)
Patients with olaparib dose interruption 18 (78) 18 (82)
 Due to AE 9 (39) 10 (45)
  Lasting ≥3 days 8 (35) 9 (41)
  Lasting ≥14 days 3 (13) 1 (5)
Patients with olaparib dose reductiona 4 (17) 2 (9)
 Due to AE 3 (13) 2 (9)
 Due to physician decision 2 (9) 0
Patients with olaparib permanently discontinued 20 (87) 16 (73)
Olaparib treatment ongoing 3 (13) 6 (27)
Durvalumab
Median (range) of durvalumab cycles 4 (1–24)
Patients with ≥1 durvalumab cycle omitted 2 (9)
Patients with durvalumab permanently discontinued 16 (73)
Durvalumab treatment ongoing 6 (27)

Note: Data are n (%) unless otherwise specified.

Abbreviation: AE, adverse event.

aMore than one reason possible.