Table 1.
HPV (+) OPSCC patient characteristics.
| Patient characteristics (n = 106) | No. (%) |
|---|---|
| Gender | |
| Male | 97 (91.5) |
| Female | 9 (8.5) |
| Median age (years) | 61 |
| Median follow-up (months) | 24.9 |
| Progressed during follow-up | 96 (91) |
| Survived throughout follow-up | 102 (96) |
| Smoking history | |
| >10 Pack years | 47 (44.3) |
| <10 Pack years | 11 (10.4) |
| Never smoker | 48 (45.3) |
| Primary tumor site | |
| Tonsil | 55 (51.9) |
| Base of tongue | 42 (39.6) |
| Palatine tonsil | 2 (1.9) |
| Glossotonsillar sulcus | 3 (2.8) |
| Unknown primary tumor | 4 (3.8) |
| Histology | |
| Nonkeratinizing SCC | 95 (89.6) |
| Othera | 11 (10.4) |
| AJCC 8 pathologic T stage | |
| pT0 | 6 (5.6) |
| pT1 | 48 (45.3) |
| pT2 | 48 (45.3) |
| pT3 | 2 (1.9) |
| pT4 | 2 (1.9) |
| AJCC 8 pathologic N stage | |
| pN0 | 1 (0.9) |
| pN0*b | 6 (5.7) |
| pN1 | 87 (82.1) |
| pN1*b | 82 (77.3) |
| pN2 | 18 (17) |
| ENE | |
| ENE present | 33 (31) |
| ENE absent | 73 (69) |
| Adjuvant radiotherapy | |
| 66 Gy | 5 (4.7) |
| 60 Gy | 54 (50.9) |
| 44 Gy | 1 (0.9) |
| 42 Gy | 24 (22.6) |
| Unknown dose | 1 (0.9) |
| Received adjuvant radiotherapy or chemoRTc | 85 (80.2) |
| Received adjuvant radiotherapy alone | 53 (50.0) |
| Adjuvant chemotherapy | |
| Yesd | 32 (30.2) |
| No | 74 (69.8) |
| No adjuvant treatment | |
| Definitive surgery alone | 21 (19.8) |
aOther histologic subtypes beside nonkeratinizing SCC included keratinizing SCC, adenosquamous carcinoma, lymphoepithelial carcinoma, basaloid carcinoma, and SCC not otherwise specified.
bSeven patients with AJCC 8 stage pN1 disease had excisional lymph node biopsies prior to surgery, where their positive node(s) were removed. In 5 of these patients, no additional nodes were identified at surgery, so they were effectively pN0 when lymph was collected (thus we had 6 pN0* patients, including 1 true pN0 patient). In 2 of the 7 pN1 excisional biopsy patients, additional involved nodes were found at the time of surgery, so they remained stage pN1* when lymph was collected (thus the 87 pN1 patients were reduced to 82 pN1* patients).
cPatients that received adjuvant radiotherapy or chemoradiotherapy after surgery.
dAll adjuvant chemotherapy patients also received concurrent radiotherapy.