FIG. 1.
Serum and intestinal antibody responses after intranasal immunization with 2/6-VLPs particles. Total (IgA, IgG, and IgM) serum (A) and intestinal IgG (B) and IgA (C) antirotavirus antibodies were measured in mice after three inoculations (72 days postinoculation) (left panels) with 2/6-VLPs administered intranasally with CT, LT, or LT-R192G, as indicated along the x axis, and 23 days postchallenge with ECwt (right panels). Antibody titers were measured for individual mice by ELISA, and results are plotted as the GMTs of the groups (n = 10 per group). Error bars represent one standard error of the mean. Significant differences in GMTs (P < 0.05), measured by Mann-Whitney U, within a panel are indicated (∗, @, and #).