Figure 6.

Carboxylated NPs have an increased biofilm association compared to sulfated NPs. (A) Chemical structure of either the dextran or vinyl hydrocarbon backbone, showing functional group differences between CMD and DXS, as well as PAA and PVS. (B) Pearson’s coefficient with biofilms produced by mucA22 or PAO1 of CMD and DXS or PAA and PVS. Student’s t-test was used for each pair of polymer backbones, where ** means p < 0.01. N = 4 independent biofilms were tested with N = 4–5 images per biofilm, though colocalization data of 1.0 were considered artifacts of the image analysis software and were excluded.