Study	Reason for exclusion
Akaza 1993	Comparison of other androgen suppression therapies
Akaza 2003	Comparison of other androgen suppression therapies
Alberts 2006	Patients not fitting to inclusion criteria. Comparison of other androgen suppression therapies
Aso 1993a	Comparison of other androgen suppression therapies
Aso 1993b	Comparison of other androgen suppression therapies
Auvinen 2004	Different topic
Ayub 1990	Comparison of other androgen suppression therapies
Blackledge 1996	Not a randomised controlled study (review article)
Boccardo 2002	Comparison of other androgen suppression therapies
Bono 2007	Not a randomised controlled study. Patients not fitting to inclusion criteria
Bruun 1996	Comparison of other androgen suppression therapies
Chang 1996	Comparison of other androgen suppression therapies
Chatelain 1994	Comparison of other androgen suppression therapies
Cockshott 1990	No comparison with control group
Colquhoun 2012	Different topic
Dawson 1997	Comparison of other androgen suppression therapies
Decensi 2007	Comparison of bicalutamide versus no treatment
Ekwueme 2012	Not a randomised controlled study
EPC program	Comparison of bicalutamide versus placebo
Eri 1993	Patients not fitting to inclusion criteria. Comparison of bicalutamide versus placebo
Eri 2001	Comparison of bicalutamide versus placebo. Patients not fitting to inclusion criteria
Festuccia 2007	Different topic. Comparison of other androgen suppression therapies
Gravina 2007	Different topic
Henderson 2003	Not a randomised controlled study. Different topic
Iida 2011	Comparison of other androgen suppression therapies. Not a randomised controlled study
Jacobo 1976	Comparison of other androgen suppression therapies
Johansson 1988	Comparison of other androgen suppression therapies
Jones 1994	Not a randomised controlled study
Kaisary 1994	Not a randomised controlled study
Kariakin 2001	No comparison with control group
Kasimis 2000	Not a randomised controlled study
Kotake 1996a	Not a randomised controlled study
Kotake 1996b	Comparison of different doses of bicalutamide (no comparison with castration)
Kulkarni 2003	Comparison of other androgen suppression therapies
Lazzaro 2007	Different topic
Lee 2009	Comparison of other androgen suppression therapies. Randomised cross‐over study. Patients not fitting to inclusion criteria
Lee 2010	Comparison of other androgen suppression therapies. Randomised cross‐over study. Patients not fitting to inclusion criteria
Lehmusvaara 2012	Not a randomised controlled study. Different topic
Lin 2011	Comparison of other androgen suppression therapies
Lissoni 2002	No comparison with control group
Loran 2001	Comparison of other androgen suppression therapies. Not a randomised controlled study. Patients not fitting to inclusion criteria
Lund 1988	Comparison of other androgen suppression therapies
Lunglmayr 1995	No comparison with control group
McGivern 2011	Different topic. Not a randomised controlled study
McGivern 2012	Different topic. Not a randomised controlled study
Migliari 1991	Not a randomised controlled study
Migliari 1992	No comparison with control group
Motofei 2011	Not a randomised controlled study
Murphy 2004	Comparison of different doses of flutamide. No comparison with castration
Newling 1989	Not a randomised controlled study
Noldus 1996	Comparison of other androgen suppression therapies
Nyman 2005	Not a randomised controlled study. Different topic
Oosterlinck 1996	Comparison of other androgen suppression therapies. Not a randomised controlled study
Ostri 1991	Comparison of other androgen suppression therapies
Petit 2008	Not a randomised controlled study
Prezioso 2007	Not a randomised controlled study
Raina 2007	Not a randomised controlled study
Raynaud 1988	Not a randomised controlled study
Scattoni 2006	Comparison of bicalutamide versus no treatment
Scher 1997	No comparison with control group. Patients not fitting to inclusion criteria
Schröder 2000	Comparison of other androgen suppression therapies
Schröder 2004	Comparison of other androgen suppression therapies
Sciarra 2004b	Not a randomised controlled study
See 2004	Not a randomised controlled study
Shipley 2011	Comparison of bicalutamide versus placebo
Smith 2003	Not a randomised controlled study
Soloway 1996	No comparison with control group
Thorpe 1996	Comparison of other androgen suppression therapies
Thrasher 2000	Comparison of other androgen suppression therapies
Tyrrell 1998	No comparison with castration
Verhelst 1994	No comparison with control group
Wadhwa 2009	Not a randomised controlled study
Wadhwa 2011	Not a randomised controlled study
Wirth 2004	Comparison of flutamide versus no treatment
Yoshimura 2003	Not a randomised controlled study. Different topic
Zanardi 2009	Patients not fitting to inclusion criteria. Not a randomised controlled study
Zhigang 2008	Patients not fitting to inclusion criteria. Comparison of flutamide with placebo