Figure 4.

Change in VA (LS-mean VA) from baseline to 12 and 24 months (mITT vs. matched NH)

Difference in change of LS-mean VA from baseline to visit time point between treated eyes and matched eyes in the NH group (delta VA) were calculated using analysis of covariance (ANCOVA) with fixed factors of treatment, gender, mutation, and VA at baseline as a covariate. Error bars indicate 95% confidence limits. ns p > 0.05; ∗p ≤ 0.05; ∗∗p ≤ 0.01; ∗∗∗p ≤ 0.001. See also Figure S5 and Table S8. ns, nonsignificant.