Table 1. Overview of included patients for the whole cohort, cohort 1 (C1) and cohort 2 (C2).
| Group | All | C1 | C2 | |
|---|---|---|---|---|
| N | 179 | 105 | 74 | |
| Age (range) | 66 (26 - 96) | 66 (26 - 96) | 68 (45 - 82) | |
| Sex (%) | F | 72 (40%) | 57 (54%) | 15 (20%) |
| M | 107 (60%) | 48 (46%) | 59 (80%) | |
| RNA-seq [Yes/No] | 142 (79%) | 85 (81%) | 57 (77%) | |
|
RNA classification (%) SCLC-GRC |
SCLC-A | 75 (42%) | 47 (45%) | 28 (38%) |
| SCLC-N | 25 (14%) | 22 (21%) | 3 (4%) | |
| SCLC-P | 15 (8%) | 4 (4%) | 11 (15%) | |
| SCLC-I | 21 (12%) | 8 (8%) | 13 (18%) | |
| equivocal | 6 (3%) | 4 (4%) | 2 (3%) | |
| RRBS [Yes/No] | 124 (69%) | 83 (79%) | 41 (55%)¥ | |
|
RRBS classification (%) SCLC-DMC |
SCLC-A | 78 (44%) | 55 (52%) | 23 (31%) |
| SCLC-N | 23 (13%) | 20 (19%) | 3 (4%) | |
| SCLC-P | 11 (6%) | 3 (3%) | 8 (11%) | |
| SCLC-I | 11 (6%) | 5 (5%) | 6 (8%) | |
| equivocal | 1 (1%) | 0 (0%) | 1 (1%) | |
| Both [RNA-seq & RRBS] | 100 (56%) | 66 (63%) | 34 (46%) | |
¥
For 15/74 samples (21%) only previously extracted RNA was available and thus no RRBS could be performed. Excluding those samples, success rate for RRBS was 72% (41/57) for C2 and 76% (124/164) for the complete data set.