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. 2024 Mar 18;67(6):4707–4725. doi: 10.1021/acs.jmedchem.3c02308

Table 3. In Vivo PK Exposure of M4K2304, M4K2306, M4K2308, and M4K2281.

Compound C @ 0.5 h (nM) C @ 1 h (nM) C @ 2 h (nM) C @ 6 h (nM) C @ 24 h (nM)
M4K2009 3021 4276 7489 13,432 1542
M4K2308 (32) 729 1069 1117 1890 63
M4K2281 (33) 3647 5053 3533 2233 0
M4K2304 (41) 323 466 523 1260 336
M4K2306 (42) 134 254 277 300 17