Table 3. In Vivo PK Exposure of M4K2304, M4K2306, M4K2308, and M4K2281.
Compound | C @ 0.5 h (nM) | C @ 1 h (nM) | C @ 2 h (nM) | C @ 6 h (nM) | C @ 24 h (nM) |
---|---|---|---|---|---|
M4K2009 | 3021 | 4276 | 7489 | 13,432 | 1542 |
M4K2308 (32) | 729 | 1069 | 1117 | 1890 | 63 |
M4K2281 (33) | 3647 | 5053 | 3533 | 2233 | 0 |
M4K2304 (41) | 323 | 466 | 523 | 1260 | 336 |
M4K2306 (42) | 134 | 254 | 277 | 300 | 17 |