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. 2024 Mar 12;67(6):4463–4482. doi: 10.1021/acs.jmedchem.3c01115

Table 2. IC50 (μM) Values of Synthesized Complexes Calculated from Percent (%) Viability Values in Different Cell Lines.

Comp HepG2 Caco-2 HT-29 MCF-7 A549 HEK293T
Ru1S 26.51 ± 10.43 18.61 ± 4.96 64.0 ± 22.62 17.18 ± 3.84 131.48 ± 22.83 169.48 ± 97.97
Ru2S 78.84 ± 42.81 10.98 ± 2.47 19.41 ± 5.58 17.96 ± 5.55 94.15 ± 14.76 144.43 ± 158.6
Ru3S 7.13 ± 2.12 9.57 ± 2.33 6.93 ± 1.76 12.09 ± 3.36 25.24 ± 2.87 83.79 ± 58.05
Ru4S 23.76 ± 4.23 2.47 ± 0.42 6.24 ± 1.36 5.35 ± 0.78 29.90 ± 4.48 33.15 ± 9.17
Ru5S 27.36 ± 5.62 11.44 ± 3.76 21.88 ± 7.19 9.47 ± 1.96 34.72 ± 4.78 87.34 ± 35.95
Ru6S 54.79 ± 28.65 12.42 ± 2.75 41.77 ± 11.88 19.33 ± 4.09 65.03 ± 12.40 66.15 ± 18.46
Ru7S 30.01 ± 6.51 17.01 ± 4.25 14.60 ± 3.46 10.11 ± 2.65 172.97 ± 57.41 764.61 ± 188
Ru8S 25.65 ± 4.43 20.45 ± 4.80 33.56 ± 10.17 33.07 ± 12.50 92.36 ± 19.80 16.55 ± 18.32
Srf 5.20 ± 1.66 13.80 ± 3.89 7.89 ± 2.53 10.55 ± 2.60 7.48 ± 0.86 0.15 ± 0.16