| Catalysis |
Glucose oxidase |
ZIF-8, PCN-224(Fe) |
Glucose oxidation |
high stability, construction
of multienzyme
system for cascade
reaction |
(57−61) |
| |
Catalase |
UiO-66,
ZIF-8, ZIF-90, MIL-101 |
Reduction of hydrogen peroxide |
Retained enzyme activity at harsh conditions; preserved capability
for adsorbed molecules |
(53,62−66) |
| |
Lipase |
UiO-66,
ZIF-67, MOF-74, ZIF-8 |
Hydrolysis reactions |
Protective activity against harsh condition; integration for
cascade reaction |
(67−71) |
| |
Cytochrome c
|
NKMOF-101/102, ZIF-8,
PCN-222,
UiO-66 |
Removal of hydrogen peroxide; oxidation of ABTS |
Boosted enzymatic activity compared with free enzyme |
(41,72,73) |
| |
Cellulase |
UiO-66-NH2, ZIF-8 |
Cellulose
hydrolysis |
Improved enzyme stability and shelf life;
tolerance to ionic
liquid |
(74,75) |
| |
β-Galactosidase |
UiO-66-NH2,
ZIF-8 |
Hydrolysis of cellobiose |
Increased
resistance to protease and acidic conditions |
(76) |
| |
Formate
dehydrogenase |
NU-1006, MIL-125-NH2
|
CO2 fixation, formic
acid production |
Enhanced activity for efficient CO2 fixation |
(77,78) |
| |
Horseradish peroxidase |
ZIF-8 |
Evaluations of enzyme activities |
Enhanced activity,
thermostability, and recyclability |
(50,79) |
| |
Catechol oxidase |
MOF-818 |
Oxidation of catechol |
Similar
activity to the oxidase with specificity |
(80) |
| Electrochemical catalysis |
Pepsin |
ZIF-8 modified with Ni2+
|
Oxygen evolution reaction |
Stabilization and reduced
overpotential for reaction |
(81) |
| |
Formate dehydrogenase |
In(III)-Ni MOF, NU-1006 |
CO2 fixation, formic acid production |
Enhanced CO2 absorption and stability; higher yield
compared with free enzymes |
(82,83) |
| Biosensing |
Glucose oxidase |
MAF-2, Fe-MIL-88B-NH2, Cu-BTC, ZIF-8 |
Glucose detection |
Enhanced
sensing activity, improved thermostability, and low
detection limit |
(84−87) |
| |
Horseradish
peroxidase |
ZIF-8, ZIF-90, amorphous ZIFs |
Signal generation for quantification |
Protective effect
on enzyme; combination or cascade with other
enzymes |
(88−91) |
| |
Cholesterol oxidase |
PCN-333 |
Cholesterol detection |
Improved
stability and sensitivity |
(92) |
| Biomedicine |
Glucose oxidase |
ZIF-8, PCN-224, Cu-TCPP(Fe) |
Consumption of endogenous glucose and oxygen |
High catalytic activity to induce starvation and synergize
with prodrug; Low biotoxicity |
(93−96) |
| |
Catalase |
ZIF-8, MOF-808, MIL-101-NH2
|
Removal of toxic molecule; generation of oxygen in
hypoxia |
Preserved enzymatic activity in physiological
conditions |
(97−99) |
| |
Tyrosinase |
PCN-333(Al) |
Activate prodrug for cancer therapy |
High activity and stability in acid condition |
(100) |
| |
Superoxide
dismutase |
ZIF-zni |
Relieve oxidative stress |
Protection against acidic conditions; high therapeutic efficacy |
(101) |
| |
l-Methioninase |
UiO-66 |
Consumption of l-methionine in cells |
Improved
enzyme stability |
(102) |
