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. 2024 Feb 29;5(3):101445. doi: 10.1016/j.xcrm.2024.101445

Figure 3.

Figure 3

CF501/RBD-Fc elicited potent and durable cross-neutralizing antibodies against XBB.1.5, XBB.1.16, CH.1.1, EG.5, BA.2.86, and JN.1 in sera of rhesus macaques

(A–F) Evaluation of the titers of cross-neutralizing antibodies against pseudotyped XBB.1.5 (A), XBB.1.16 (B), CH.1.1 (C), EG.5 (D), BA.2.86 (E), and JN.1 (F) in sera of CF501/RBD-Fc- or Alum/RBD-Fc-immunized rhesus macaques collected from days 28 to 191 post-first immunization. The dashed line represents the limit of detection, and 1:100 was defined as the limit of detection. Data are shown as mean ± SEM. The experiments were repeated a minimum of two times. Two-way ANOVA was used to compare NT50s between CF501/RBD-Fc and Alum/RBD-Fc. ∗p < 0.05, ∗∗p < 0.01, and ∗∗∗p < 0.001.

(G) Correlation matrices showed Pearson correlations between any two parameters among the binding IgG titers and neutralizing titers against XBB.1.5, XBB.1.16, CH.1.1, EG.5, BA.2.86, and JN.1. The color and size of circle represent correlation values. ∗p < 0.05, ∗∗p < 0.01, and ∗∗∗p < 0.001.

(H) Fold changes in NT50s against XBB.1.5, XBB.1.16, CH.1.1, EG.5, BA.2.86, and JN.1 compared to D614G for sera collected at day 136 post-first immunization.