Figure 4.

In vivo 1C-MIM intervention accelerates motor recovery from CTX injury

(A) Experimental design. The drinking intervention is maintained during all times, including 3 months before the CTX injection and 8 days of recovery after CTX. The day of CTX injection is marked in the center as “0,” followed by 8 days of recovery. The green bar before CTX marks the period of behavioral preconditioning of mice to the open field test (OFT), and the orange bar after CTX marks the tracking of recovery by the OFT.

(B) Representative tracks of behavioral motor test performed in control and 1C-MIM-supplemented mice 24 h after CTX injury.

(C) Kinetics of resting, evaluated by OFT in CTX-injured mice. The resting time was recorded at 1, 5, and 8 days after cardiotoxin injury during a 60 min session. Preconditioning was performed in all animals 1 week before injury and considered as net 100% for subsequent analyses.

(D) Kinetics of jumps, velocity, and ambulatory time, evaluated by OFT in CTX-injured mice. These were recorded 1, 4 , 5 , and 7 days after cardiotoxin injury during a 60 min session. Preconditioning was performed in all animals 1 week before the injury.

Total intervention n = 87 mice. Pair comparisons at indicated groups are in Figure S6A.

See also Figures S5 and S6.