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. 2024 Mar 8;5(3):101448. doi: 10.1016/j.xcrm.2024.101448

Figure 4.

Figure 4

Tfh-like, dysfunctional CD8+ T, and GC B cells form a TLS

(A) Correlation of lineage-normalized cell-type frequencies in 33 IAC tumors.

(B) Expression of selected genes in IAC-infiltrating T cell clusters.

(C) Volcano plots showing differentially expressed genes (DEGs) of TCGA patients with LUAD in stage I grouped by the expression levels of CD4 and CXCL13 (STAR Methods).

(D) Heatmap showing the expression of ligand-receptor pairs highly expressed in B and T cells.

(E) Tumor sections from patients with IAC stained with anti-CXCL13 mAb (red), anti-CD20 mAb (green), anti-CD4 mAb (yellow), anti-CD8 mAb (cyan), and DAPI (blue). Scale bars, 50 and 10 μm.

(F) Scatterplots showing gene expression of the 50 TLS gene signature scores (y axis) with the difference of Tfh-like signature scores (x axis).

(G) Scatterplots showing gene expression of dysfunctional CD8+ T signature scores (y axis) with the difference of Tfh-like signature scores (x axis).

(H) Scatterplots showing gene expression of the 50 TLS gene signature scores (y axis) with the difference of dysfunctional CD8+ T signature scores (x axis).