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. 2024 Mar 21;5(3):101469. doi: 10.1016/j.xcrm.2024.101469

Figure 1.

Figure 1

T cell infiltration and sustained HLA expression in FLC tumors

(A) Immunofluorescence of FLC-SJ5 tumor tissue. Blue, DAPI; red, CD3; green, CD8; white, CD68. Shown is a bar plot quantification of CD3+CD8+ T cells vs. CD3+CD8− T cells.

(B) HLA expression levels from 24 FLC patients, classified by sample type. NML, tumor-adjacent non-malignant liver; LIV, primary or recurrent liver tumor; MET, metastatic tumor. Samples from patients with matched samples across types are connected by colored lines, coded by patient ID. A dotted red line shows median HLA expression for healthy liver tissue reported by the GTEx Portal. Wilcoxon rank-sum test; ns, padj > 0.05.

(C) HLA expression levels from the patient cohort, plotted by patient and color-coded by sample location.

(D) Correlation between HLA expression and the number of predicted fusion neoepitopes for the patient cohort. R indicates the Pearson correlation coefficient.