Table 2.
Regression coefficients of WMH components and their interaction with Aβ status on cognitive domains
| Posterior Component Score | Posterior Component Score*Aβ | |||||
| Cognitive domain | β (95% CI) | p-value | Robust 95% CI | β (95% CI) | p-value | Robust 95% CI |
| Episodic Memory | -0.02 (-0.13 to 0.09) | 0.17 | -0.12 to 0.10 | -0.34 (-0.54 to -0.13) | 0.001 | -0.48 to -0.10 |
| Executive Function | -0.05 (-0.14 to 0.05) | 0.39 | -0.14 to 0.05 | -0.10 (-0.27 to 0.07) | 0.27 | -0.28 to 0.07 |
| Processing Speed | 0.03 (-0.09 to 0.14) | 0.67 | -0.08 to 0.16 | -0.01 (-0.22 to 0.20) | 0.89 | -0.22 to 0.20 |
| Deep Component Score | Deep Component Score*Aβ | |||||
| Cognitive domain | β (95% CI) | p-value | Robust 95% CI | β (95% CI) | p-value | Robust 95% CI |
| Episodic Memory | -0.05 (-0.15 to 0.051) | 0.32 | -0.14 to 0.08 | -0.24 (-0.43 to -0.05) | 0.013 | -0.35 to 0.02 |
| Executive Function | 0.04 (-0.05 to 0.12) | 0.40 | -0.4 to 0.21 | -0.07 (-0.24 to 0.09) | 0.38 | -0.25 to 0.08 |
| Processing Speed | -0.01 (-0.12 to 0.09) | 0.73 | -0.13 to 0.08 | -0.02 (-0.21 to 0.18) | 0.87 | -0.19 to 0.21 |
| Periventricular Component Score | Periventricular Component Score*Aβ | |||||
| Cognitive domain | β (95% CI) | p-value | Robust 95% CI | β (95% CI) | p-value | Robust 95% CI |
| Episodic Memory | -0.09 (-0.20 to 0.02) | 0.11 | -0.17 to 0.03 | -0.37 (-0.57 to -0.18) | < 0.001 | -0.51 to -0.14 |
| Executive Function | -0.05 (-0.14 to 0.04) | 0.17 | -0.12 to 0.07 | -0.07 (-0.24 to 0.10) | 0.41 | -0.27 to 0.08 |
| Processing Speed | 0.07 (-0.04 to 0.19) | 0.20 | -0.05 to 0.28 | -0.08 (-0.28 to 0.12) | 0.44 | -0.26 to 0.14 |
| BGT Component Score | BGT Component Score*Aβ | |||||
| Cognitive domain | β (95% CI) | p-value | Robust 95% CI | β (95% CI) | p-value | Robust 95% CI |
| Episodic Memory | -0.05 (-0.14 to 0.05) | 0.43 | -0.09 to 0.09 | -0.38 (-0.58 to -0.18) | < 0.001 | -0.53 to -0.12 |
| Executive Function | 0.07 (-0.01 to 0.15) | 0.09 | -0.01 to 0.15 | -0.02 (-0.20 to 0.15) | 0.82 | -0.21 to 0.16 |
| Processing Speed | -0.03 (-0.13 to 0.07) | 0.33 | -0.15 to 0.04 | -0.06 (-0.27 to 0.15) | 0.57 | -0.33 to 0.09 |
For Aβ status, a binarized variable with a Centiloid cutoff of 12 was used. Participants who did not complete all neuropsychological tests included in the composite scores for episodic memory (n = 3), executive function (n = 4), and processing speed (n = 1) were excluded from this analysis