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. Author manuscript; available in PMC: 2024 Dec 1.
Published in final edited form as: Nat Chem. 2023 Nov 13;15(12):1683–1692. doi: 10.1038/s41557-023-01365-0

Table 3.

Hydrotrifluoromethylation and hydrodifluoromethylation of APIs & natural product alkene derivatives.

graphic file with name nihms-1973984-t0005.jpg

Reaction conditions for hydrotrifluoromethylation: alkene (0.1mmol, 1.0 equiv.), trifluoroacetic acid (3.0 equiv.), Fe(OAc)2 (10 mol%), HAT reagent (10 mol%), Na2CO3 (10 mol%) and CH3CN/H2O (9:1, 0.1 M), 24h, RT, 390nm Kessil blue LED. Reaction conditions for hydrodifluoromethylation: alkene (0.1mmol, 1.0 equiv.), difluoroacetic acid (3.0 equiv.), Fe(NO3)3·9H2O (5 mol%), TRIP thiol (5 mol%), Na2CO3 (10 mol%) and CH3CN/H2O (9:1, 0.1 M), 24h, RT, 390nm Kessil blue LED. a With 10 mol% of TRIP thiol. b With 10 mol% of TRIP disulfide.c With Fe(OAc)2 (20 mol%), TRIP thiol (20 mol%) and trifluoroacetic acid (6 equiv.).