Table 4.
Secondary analyses for eclampsia and stillbirth
|
Hypertensive pregnant women in stratum |
Hypertensive pregnant women within risk stratum with an outcome within 2 days |
Hypertensive pregnant women within risk stratum with an outcome within 7 days |
Hypertensive pregnant women within risk stratum with an outcome at any time |
||||
|---|---|---|---|---|---|---|---|
| N (%) | N (%) | Likelihood ratios | N (%) | Likelihood ratio | N (%) | Likelihood ratio | |
| Eclampsia (N=140 maternal events, AUROC 0·80 [95% CI 0·69–0·91]) | |||||||
| Very low risk | 8 (0·7%) | 0 | −LR 0·0 (0·0 to NaN) | 0 | −LR 0·0 (0·0 to NaN) | 0 | −LR 0·0 (0·0 to NaN) |
| Low risk | 321 (29·1%) | 0 | −LR 0·0 (0·0 to NaN) | 0 | −LR 0·0 (0·0 to NaN) | 0 | −LR 0·0 (0·0 to NaN) |
| Moderate risk | 676 (61·3%) | 3 (0·4%) | .. | 3 (0·4%) | .. | 2 (0·3%) | .. |
| High risk | 87 (7·9%) | 2 (2·3%) | +LR 5·1 (1·7 to 15·3) | 2 (2·3%) | +LR 5·1 (1·7 to 15·3) | 5 (5·4%) | +LR 8·9 (5·3 to 14·8) |
| Very high risk | 11 (1·0%) | 1 (9·1%) | +LR 18·3 (2·8 to 121·3) | 1 (9·1%) | +LR 18·3 (2·8 to 121·3) | 1 (7·7%) | +LR 11·5 (1·7 to 78·3) |
| Stillbirth (N=50 stillbirths of 1925 women with informative data within the complete validation dataset, AUROC 0·79 [0·74–0·85]) | |||||||
| Very low risk | 23 (1·2%) | 0 | −LR 0·0 (0·0 to NaN) | 0 | −LR 0·0 (0·0 to NaN) | 0 | −LR 0·0 (0·0 to NaN) |
| Low risk | 601 (31·2%) | 1 (0·2%) | −LR 0·1 (0·0 to 0·4) | 1 (0·2%) | −LR 0·1 (0·0 to 0·4) | 1 (0·2%) | −LR 0·1 (0·0 to 0·4) |
| Moderate risk | 1148 (59·6%) | 32 (2·8%) | .. | 32 (2·8%) | .. | 33 (2·9%) | .. |
| High risk | 138 (7·2%) | 16 (11·6%) | +LR 5·0 (3·2 to 7·7) | 16 (11·6%) | +LR 5·0 (3·2 to 7·7) | 16 (11·6%) | +LR 4·9 (3·1 to 7·6) |
| Very high risk | 15 (0·8%) | 0 | +LR 0·0 (0·0 to NaN) | 0 | +LR 0·0 (0·0 to NaN) | 0 | +LR 0·0 (0·0 to NaN) |
Risk strata determined by diagnostic test performances for first occurrence of any component of the primary combined adverse maternal outcome within 2 days: very low risk –LR <0·1; low risk –LR 0·1 to 0·2; moderate risk +LR <5·0 and –LR >0·2; high risk +LR 5·0 to 10·0; very high risk +LR >10·0. AUROC=area under the receiver-operator characteristic. Inf=infinity. –LR=negative likelihood ratio. +LR=positive likelihood ratio. NaN=not a number. Likelihood ratios are presented in addition to stratification performance as the PIERS-ML model was not developed to predict either of these two outcomes.