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[Preprint]. 2024 Mar 22:2024.03.22.586241. [Version 1] doi: 10.1101/2024.03.22.586241

Figure 2: Characteristics of antibodies selected for validation.

Figure 2:

(A) For each generated CDRH3 (dots), shown are the percent sequence identity to CDRH3s for antibodies using the public IGHV3-53/3-66 germline gene from the CoV-AbDab database (x-axis) vs. RMSD to BD-604 (y-axis). The 14 antibodies that were selected for experimental validation are highlighted in red.

(B) For each of BD-604 and the 14 selected AI-generated antibodies (rows), shown are the CDRH3 sequence and length; the % CDRH3 sequence identity to BD-604, antibodies using the public IGHV3-53/3-66 germline gene from the CoV-AbDab database, and all antibodies from the CoV-AbDab database; and RMSD (in Å) to the BD-604 CDRH3.