Figure 5. Number of novel and reported reproductive hormone associations.

Each panel displays a different hormone (FSH=follicle-stimulating hormone, LH=luteinising hormone). Lead variants in each analysis stratum (F=female-specific, M=male-specific, all-anc=all ancestry meta-analysis, EUR=European-only meta-analysis) are classified as: (1) novel (no hormone associations) if they are not in LD (r²<0.1) with, and conditionally independent of (conditional P-value P_cond<0.05), any variants within a 1Mb window of the lead variant that are associated with 28 reproductive hormones in the GWAS Catalog⁶², plotted in pink, (2) novel for this hormone if they are not in LD (r²<0.1) with, and conditionally independent of (P_cond<0.05), the respective hormone-associated variants within a 1Mb window of the lead variant, plotted in green, and (3) reported otherwise, plotted in grey. Note the different Y-axis scales in each subplot. assocns.=associations.