Table 4.
Functionally annotated sheep gene targets of RVFV miRnas.
| Predicted microRNA | 3′ target | 5’ target | target gene | Target description | Target function (GO)* | P-value |
|---|---|---|---|---|---|---|
| RVFV 15 (L1) | * | ASH1L | Like histone lysine methyltransferase | Embryonic development | p < .00001 | |
| RVFV 30 (L2) | * | ASTN2 | Astrotactin 2 | Brain development Neurogenesis |
p < .00001 | |
| RVFV 34 (L3) | * | OXT | oxytocin/neurophysin I prepropeptide | Reproductive Functions | p < .00001 | |
| RVFV 76 (L4) | * | CAV1 | Ovis aries caveolin 1 | Signal Transduction Cellular Functions Disease Associations |
p < .00001 | |
| RVFV 83 (L5) | * | TGF-beta 3 | Ovis aries transforming growth factor-beta 3 | Development and Morphogenesis issue Repair and Regeneration |
p < .00001 | |
| RVFV 3 (L6) | * | MIP | Ovis aries major intrinsic protein of lens fiber | Cell Adhesion and Structural Integrity | p < .00001 | |
| RVFV 19 (L7) | * | ASH1L | Like histone lysine methyltransferase | Embryonic development | p < .00001 | |
| RVFV 40 (L8) | * | KITLG | Ovis aries KIT ligand | Cancer Biology Germ Cell Development |
p < .00001 | |
| RVFV 1 (M1) | * | CYP1A1 | Ovis aries cytochrome P4501A1 | Endogenous Substrates Metabolism | p < .00001 | |
| RVFV 37 (M2) | * | ACTB | Ovis aries actin beta | Cell Motility and Migration Gene Expression Regulation |
p < .00001 | |
| RVFV 39 (M3) | * | KRT25 | Ovis aries keratin 25 | Epithelial Tissue Structure | p < .00001 | |
| RVFV 50 (M4) | * | IDH1 | Ovis aries isocitrate dehydrogenase | Genetic Alterations and Disease Metabolism and Energy Production |
p < .00001 | |
| RVFV 23 (M5) | * | ASH1L | Like histone lysine methyltransferase | Embryonic development | p < .00001 | |
| RVFV 38 (M6) | * | CSN1S2 | Ovis aries alpha-s2-casein | Milk Production and Composition | p < .00001 | |
| RVFV 1 (S1) | * | IFNAR1 | Ovis aries interferon alpha and beta receptor subunit 1 | Antiviral Response | p < .00001 | |
| RVFV 2 (S2) | * | OXTR | Ovis aries oxytocin receptor | Receptor Function | p < .00001 | |
| RVFV 14 (S3) | * | ASH1L | Like histone lysine methyltransferase | Embryonic development | p < .00001 | |
| RVFV 16 (S4) | * | IDH1 | Ovis aries isocitrate dehydrogenase | Genetic Alterations and Disease Metabolism and Energy Production |
p < .00001 | |
| RVFV 20 (S5) | * | IFNAR1 | Ovis aries interferon alpha and beta receptor subunit 1 | Antiviral Response | p < .00001 |
*It is important to note that gene effects can vary depending on individual differences, contexts, and other factors.