Table 3.
The GO and KEGG Function Enrichment Analysis of FOXP3 and Neighbor Genes in BRCA
| Ontology | ID | Description | GeneRatio | BgRatio | p value | p. Adjust | q value | Count | z Score |
|---|---|---|---|---|---|---|---|---|---|
| BP | GO:0042110 | T cell activation | 101/373 | 464/18,670 | 7.76e-77 | 2.45e-73 | 1.78e-73 | 101 | 10.04987562 |
| BP | GO:0051249 | Regulation of lymphocyte activation | 91/373 | 485/18,670 | 9.46e-63 | 1.50e-59 | 1.08e-59 | 91 | 9.539392014 |
| BP | GO:0050863 | Regulation of T cell activation | 76/373 | 314/18,670 | 7.55e-61 | 7.96e-58 | 5.76e-58 | 76 | 8.717797887 |
| CC | GO:0009897 | External side of plasma membrane | 68/381 | 393/19,717 | 6.87e-45 | 1.99e-42 | 1.55e-42 | 68 | 8.246211251 |
| CC | GO:0042613 | MHC class II protein complex | 13/381 | 16/19,717 | 2.27e-20 | 3.29e-18 | 2.56e-18 | 13 | 3.605551275 |
| CC | GO:0042611 | MHC protein complex | 15/381 | 25/19,717 | 4.08e-20 | 3.94e-18 | 3.06e-18 | 15 | 3.872983346 |
| MF | GO:0004896 | Cytokine receptor activity | 25/364 | 96/17,697 | 5.92e-21 | 2.43e-18 | 1.97e-18 | 25 | 5 |
| MF | GO:0042287 | MHC protein binding | 15/364 | 40/17,697 | 9.45e-16 | 1.94e-13 | 1.57e-13 | 15 | 3.872983346 |
| MF | GO:0019955 | Cytokine binding | 22/364 | 128/17,697 | 1.70e-14 | 2.01e-12 | 1.63e-12 | 22 | 4.69041576 |
| KEGG | hsa05330 | Allograft rejection | 23/238 | 38/8076 | 2.25e-26 | 4.91e-24 | 3.77e-24 | 23 | 4.795831523 |
| KEGG | hsa04060 | Cytokine-cytokine receptor interaction | 51/238 | 295/8076 | 6.13e-26 | 6.39e-24 | 4.91e-24 | 51 | 7.141428429 |
| KEGG | hsa04514 | Cell adhesion molecules | 38/238 | 149/8076 | 8.80e-26 | 6.39e-24 | 4.91e-24 | 38 | 6.164414003 |