Table 3.
Comparison of Motor Nerve Amplitude Before and After Nusinersen Treatment in SMA Patients
Nerve | Location | Side | Amplitude(mV)Median (P25, P75) | Kruskal–Wallis Test Statistic H-value | p | ||
---|---|---|---|---|---|---|---|
T0 (n=42) | T6 (n=42) | T14 (n=21) | |||||
Median Nerve | Distal | Right | 6.115(3.9,9.2) | 6.075(4.6,8.3) | 5.710(4.3,7.7) | 0.148 | 0.928 |
Left | 4.570(3.1,8.4) | 5.740(3.3,8.5) | 6.420(3.7,10.1) | 1.693 | 0.429 | ||
Proximal | Right | 5.080(3.0,7.8) | 5.120(3.7,7.6) | 4.800(3.4,6.1) | 0.251 | 0.882 | |
Left | 4.070(2.3,6.6) | 4.950(2.2,6.9) | 4.700(3.3,7.5) | 1.505 | 0.471 | ||
Ulnar nerve | Distal | Right | 2.065(1.2,4.9) | 2.495(0.9,4.3) | 2.040(1.5,4.3) | 0.014 | 0.993 |
Left | 1.985(1.0,4.0) | 2.160(1.1,4.9) | 2.230(1.5,4.2) | 0.532 | 0.767 | ||
Proximal | Right | 2.360(1.0,4.8) | 2.355(1.3,4.5) | 1.930(1.0,3.6) | 0.526 | 0.769 | |
Left | 1.955(0.9,4.7) | 2.240(1.1,4.8) | 2.180(1.2,3.6) | 0.154 | 0.926 | ||
Axillary nerve | Right | 4.480(1.6,7.0) | 4.420(2.0,8.3) | 3.590(2.5,4.5) | 1.329 | 0.514 | |
Left | 3.235(1.7,6.8) | 3.170(1.9,8.4) | 3.270(2.0,4.4) | 0.535 | 0.765 | ||
Common peroneal nerve | Proximal | Right | 2.450(0.9,4.4) | 3.195(1.1,4.9) | 2.200(0.7,3.4) | 1.736 | 0.42 |
Left | 2.665(1.7,4.5) | 2.620(1.3,4.3) | 1.840(0.9,3.7) | 2.558 | 0.278 | ||
Distal | Right | 2.375(1.0,4.5) | 3.825(1.4,5.3) | 1.770(0.8,3.6) | 2.028 | 0.363 | |
Left | 2.820(1.0,5.1) | 2.695(1.1,4.4) | 1.820(0.9,2.7) | 2.417 | 0.299 | ||
Tibial nerve | Proximal | Right | 1.630(0.9,4.2) | 1.995(0.8,4.2) | 1.790(0.5,4.2) | 0.158 | 0.924 |
Left | 1.565(0.5,5.2) | 1.770(0.7,4.4) | 1.520(0.4,2.7) | 0.865 | 0.649 | ||
Distal | Right | 2.705(1.3,5.6) | 2.870(1.1,5.6) | 2.030(1.1,4.4) | 0.52 | 0.771 | |
Left | 2.200(0.8,6.4) | 2.285(0.9,5.6) | 2.170(1.1,4.9) | 0.045 | 0.978 | ||
Femoral nerve | Right | 0.415(0.2,1.0) | 0.685(0.2,1.7) | 0.970(0.2,2.0) | 1.724 | 0.422 | |
Left | 0.495(0.1,0.9) | 0.675(0.2,1.2) | 0.590(0.3,1.5) | 1.746 | 0.418 |