Cook 1986.
| Methods | Randomized controlled trial. Methods of randomization and blinding were not described Duration: not described |
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| Participants | Number: 101 participants scheduled for lower‐limb vascular surgery. Participants were randomly assigned to receive general or spinal anaesthesia Inclusion criteria: lower‐limb vascular surgery Exclusion criteria: not described |
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| Interventions | Spinal anaesthesia was performed with hyperbaric cinchocaine 0.5% (7 to 8 mg) with adrenaline (0.1 to 0.2 ml) 1:1000 using a 22G spinal needle in the mid‐lumbar region and in the lateral position General anaesthesia with thiopental, fentanyl (1.5 to 2.0 ug/kg), pancuronium or alcuronium, nitrous oxide and halothane was performed |
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| Outcomes |
Blood loss was not assessed in the review. |
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| Notes | Location: United States of America Settings: operating room and general hospital Source of funding: not described We contacted the author to clarify the methods of randomization and concealment allocation but did not receive an answer |
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| Risk of bias | ||
| Bias | Authors' judgement | Support for judgement |
| Random sequence generation (selection bias) | Unclear risk | Comment: no information provided |
| Allocation concealment (selection bias) | Unclear risk | Comment: The method of concealment was not described |
| Blinding of participants and personnel (performance bias) All outcomes | Unclear risk | Comment: insufficient information to permit the judgement. Blinding for participants and personnel probably was not done |
| Blinding of outcome assessment (detection bias) All outcomes | Unclear risk | Comment: insufficient information to permit the judgement. Blinding for outcome assessor probably was not done |
| Incomplete outcome data (attrition bias) All outcomes | High risk | One year: 11/50 missing from intervention group; 4/51 missing from control group. Participants were lost during the follow‐up time |
| Selective reporting (reporting bias) | Low risk | The outcome data were reported adequately |
| Other bias | High risk | The authors reported that more elderly people and smokers were included in the general anaesthesia group |