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Antiproliferative activity of investigated compounds.
| Compound | Antiproliferative activity (IC50, μM) | SI | ||
|---|---|---|---|---|
| A375 cells | 35404 cells | Fibroblasts | ||
| 7a | IN | IN | IN | n/a |
| 7b | 3.5±3.1 | >10 | >10.0 | >3 |
| 7c | 4.3±3.5 | >10 | >10.0 | >2 |
| 7d | IN | IN | IN | n/a |
| 7e | IN | IN | IN | n/a |
| 7f | IN | IN | IN | n/a |
| 7g | >10 | 0.4±0.2 | 8.1±3.6 | >20 |
| 7h | IN | IN | IN | n/a |
| 7i | >10 | >10 | >10 | n/a |
| 7j | >10 | >10 | >10 | n/a |
| Colchicine | 9±4 [nM] | - | - | n/a |
IC50 values are expressed as mean±standard deviation (n=4 each). IN: inactive; SI: selectivity index.
