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Cartoon homology model of full-length ABCA7. A homology model of full-length ABCA7 was generated using MODELLER [109] based on the alignment with the ABCA1 structure (PDB: 5xjy) and validated using the Structural Analysis and Verification Server (SAVES) server [110, 111]. AD-associated variants (Table 1) are noted and highlighted here as spheres. ECD, extracellular domain; TMD, transmembrane domain; NBD, nucleotide binding domain; RD, regulatory domain.
