Table 1.

ABCA7 SNPs associated with AD in various racial/ethnic groups^a

SNP	Mutation	Populations Associated with AD	Frequencyb	Effect Size	Sources
rs3752232	Thr319Ala	African American/Black	27.2% AD		N’Songo et al. 2017 [40]
			23.2% CN	1.24	Logue et al. 2018 [43]
rs3752239	Asn718Thr	African American/Black	1.8% AD 0.4% CN	4.06	N’Songo etal. 2017 [40]
rs3752246	Gly1527Ala	Multiple racial groups	ND	1.35	Feheretal. 2019 [113]; Hollingworth et al. 2011 [44];
				1.15	Naj etal. 2011 [45]
rs3764647	His395Arg	African American/Black	26.2–29.8% AD	1.32	Logue et al. 2011 [39];
			21.6–23.1% CN	1.29	Logue et al. 2018 [43]
				1.47	N’Songo etal. 2017 [40]
rs3764650	Intron variant	African American/Black	ND		Hohman et al. 2016 [24];
				1.27	Logue et al. 2011 [39]
		Asian		8.32	Li etal. 2017 [114];
				1.09	Zhou etal. 2017 [115]
		Colombian		1.7	Moreno et al. 2017 [37]
		Non-Hispanic White		1.25	Almeida et al. 2018 [38];
				1.25	Zhou etal. 2017 [115]
		Multiple racial groups		1.23	Hollingworth et al. 2011 [44]
rs4147929		Danish	ND	1.07	Kjeldsen et al. 2017 [35]
		Non-Hispanic White		1.66	Monsell etal. 2017 [116]
		Multiple racial groups		1.15	Lambert et al. 2013 [46]
rs59851484		African American/Black	14.8% AD 10.5% CN	1.49	Logue et al. 2018 [43]
rs78117248	Intron variant	Belgian	3.8% AD	2.07	Cuyvers et al. 2015 [36]
			1.8% CN
		Non-Hispanic White	ND	1.56	Kunkle etal. 2017 [117]
rs115550680		African American/Black	ND	1.79	Reitz et al. 2013 [23]
rs142076058	Arg578Alafs	African American/Black	9.2–15.2% AD	2.13	Cukier et al. 2016 [3]
			7.4–9.7% CN	1.27	Logue et al. 2018 [43]
rs200538373	Splice donor variant	Icelandic	ND	1.91	Steinberg et al. 2015 [34]
		Non-Hispanic White		2.12	Kunkle etal. 2017 [117]
rs567222111	Leu396fs	African American/Black	1.1% AD 0.3% CN	2.42	Logue et al. 2018 [43]

^aUpdated from [118].

^bND indicates that this information was not available for the denoted SNP. SNP, single nucleotide polymorphism; AD, Alzheimer’s disease; CN, cognitively normal.