FIGURE 1.

Z scores of the log‐transformed blood‐based biomarkers of Alzheimer's disease at different visits, among cognitively unimpaired, incident mild cognitive impairment (MCI), and incident Alzheimer's disease (Dem). Mean (95% confidence interval [CI]) of the biomarker levels (Y axis) at visits 1, 2, and 3 (X axis), in cognitively unimpaired, incident MCI, and incident dementia participants. Z scores of the log‐transformed biomarker levels are presented for the convenience of presentation. Blue represents Log₁₀ p‐tau181, green represents Log₁₀ NfL, red represents Log₁₀ GFAP, orange represents Log₁₀ Aβ42/Aβ40, and brown represents Log₁₀ p‐tau181/Aβ42. Aβ, amyloid beta; GFAP, glial fibrillary acidic protein; NfL, neurofilament light chain; p‐tau, phosphorylated tau.