TABLE 3.

Coefficients of linear mixed‐effects models' three‐way interaction (weeks:NODDI:rTMS[active]) predicting a decrease in craving VAS/total BIS‐11 using baseline NODDI metrics from frontostriatal circuits' WM tracts.

WM‐ROI	Estimate	Std. error	df	Effect size	p value	FDR a
ICVF|Cocaine craving Visual Analogue Scale (VAS)
Caud2Medulla	22.61	7.93	40.12	1.338	0.007 a	0.023 a
Caud2Palli	21.13	6.95	40.17	1.363	0.004 a	0.020 a
Thal2Medulla	16.30	6.17	40.07	1.321	0.012 a	0.030 a
Thal2Palli	21.92	6.61	40.13	1.430	0.002 a	0.020 a
ISOVF|Barratt Impulsivity Scale Version 11 (total BIS‐11)
DLPFC2rvmPFC	−49.81	23.25	39.63	1.298	0.038 a	0.190
vmPFC2DLPFC	−103.78	40.96	40.51	1.364	0.015 a	0.150
OD|Barratt Impulsivity Scale Version 11 (total BIS‐11)
DLPFC2rvmPFC	−56.76	23.43	39.80	1.245	0.020 a	0.100
CCforcepsMajor	143.70	58.05	40.24	1.177	0.018 a	0.100
$\mathit{\text{Score}}={\beta }_0+{\beta }_1·\mathit{\text{weeks}}+{\beta }_2·{\mathit{\text{NODDI}}}_{{\mathit{ROI}}_i}+{\beta }_3·\mathit{\text{rTMS}}\left[\mathit{\text{active}}\right]+{\beta }_4·\mathit{age}+{\beta }_5·\mathit{\text{educationyears}}+{\beta }_6·\mathit{\text{weeks}}·{\mathit{\text{NODDI}}}_{{\mathit{ROI}}_i}+{\beta }_7·\mathit{\text{weeks}}·\mathit{\text{rTMS}}\left[\mathit{\text{active}}\right]+{\beta }_8·{\mathit{\text{NODDI}}}_{{\mathit{ROI}}_i}·\mathit{\text{rTMS}}\left[\mathit{\text{active}}\right]+{\beta }_9·{\mathit{\text{NODDI}}}_{{\mathit{ROI}}_i}·\mathit{age}+{\beta }_{10}·{\mathit{\text{NODDI}}}_{{\mathit{ROI}}_i}·\mathit{\text{educationyears}}+{\beta }_{11}·\mathit{\text{weeks}}·{\mathit{\text{NODDI}}}_{{\mathit{ROI}}_i}·\mathit{\text{rTMS}}\left[\mathit{\text{active}}\right]$

Abbreviations: Caud2Medulla, WM connecting left caudate nucleus and axial section through medulla; Caud2Palli, WM connecting left caudate nucleus and left pallidum; CCforcepsMajor, forceps major of corpus callosum (control WM); DLPFC2rvmPFC, WM connecting left rostral middle frontal cortex (RMFC) and right medial orbitofrontal cortex (MOC); Thal2Medulla, WM connecting left thalamus and axial section through medulla; Thal2Palli, WM connecting left thalamus and left pallidum; vmPFC2DLPFC, WM connecting left MOC and left RMFC; Std., standard; df; degrees of freedom; NODDI, neurite orientation dispersion and density imaging model; rTMS, repetitive transcranial magnetic stimulation.

^a False discovery rate (FDR) adjustment was implemented with p values of their own metric, full values are found in Tables S4–S12.