TABLE 3.
Findings from regression analyses utilizing mean bacterial load by each of the 11 bacterial species analyzed using checkerboard DNA‐DNA hybridizations as exposures and the MRI features as outcomes
| Mean bacterial load | Cerebral microbleeds | Infarcts | White matter hyperintensity volume | Hippocampal volume | Entorhinal cortex volume | AD signature |
|---|---|---|---|---|---|---|
| P. gingivalis | ||||||
| Simple regression | 1.001 | 0.999 | 0.0000 | 0.0000 | −0.0002 | −0.0001 |
| Model 1 | 1.001 | 0.999 | 0.0001 | 0.0000 | −0.0002 | −0.0001 |
| Model 2 | 0.999 | 0.999 | 0.0001 | 0.0000 | −0.0002 | −0.0001 |
| Model 3 | 1.001 | 0.999 | 0.0001 | 0.0000 | −0.0002 | −0.0001 |
| P. intermedia | ||||||
| Simple regression | 1.000 | 1.000 | −0.0004 | 0.0000 | −0.0001 | 0.0000 |
| Model 1 | 0.993 | 1.000 | −0.0004 | 0.0000 | −0.0001 | 0.0000 |
| Model 2 | 1.052 | 1.000 | −0.0003 | 0.0000 | −0.0001 | 0.0000 |
| Model 3 | 1.000 | 1.000 | −0.0003 | 0.0000 | −0.0001 | 0.0000 |
| T. forsythia | ||||||
| Simple regression | 1.000 | 1.000 | 0.0002 | 0.0000 | −0.0002 | 0.0000 |
| Model 1 | 1.000 | 1.000 | 0.0002 | 0.0000 | −0.0002 | 0.0000 |
| Model 2 | 1.000 | 1.000 | 0.0002 | 0.0000 | −0.0002 | 0.0000 |
| Model 3 | 1.000 | 1.000 | 0.0002 | 0.0000 | −0.0002 | 0.0000 |
| A. actinomycetemcomitans | ||||||
| Simple regression | 0.993 | 0.998 | −0.0022 | 0.0000 | 0.0004 | 0.0002 |
| Model 1 | 0.994 | 0.998 | −0.0015 | 0.0000 | 0.0001 | 0.0002 |
| Model 2 | 0.994 | 0.998 | −0.0018 | 0.0000 | 0.0001 | 0.0002 |
| Model 3 | 0.994 | 0.998 | −0.0018 | 0.0000 | 0.0001 | 0.0002 |
| F. nucleatum | ||||||
| Simple regression | 1.000 | 1.000 | 0.0001 | 0.0000 | 0.0000 | 0.0000 |
| Model 1 | 1.000 | 1.000 | 0.0001 | 0.0000 | 0.0000 | 0.0000 |
| Model 2 | 1.000 | 1.000 | 0.0001 | 0.0000 | 0.0000 | 0.0000 |
| Model 3 | 1.000 | 1.000 | 0.0001 | 0.0000 | 0.0000 | 0.0000 |
| T. denticola | ||||||
| Simple regression | 0.998 | 1.000 | −0.0011 | 0.0000 | −0.0003 | 0.0000 |
| Model 1 | 0.998 | 1.001 | −0.0005 | 0.0000 | −0.0005 | −0.0001 |
| Model 2 | 0.998 | 1.001 | −0.0006 | 0.0000 | −0.0005 | −0.0001 |
| Model 3 | 0.998 | 1.001 | −0.0006 | 0.0000 | −0.0005 | −0.0001 |
| M. micros | ||||||
| Simple regression | 1.002 | 1.000 | −0.0001 | 0.0000 | 0.0000 | 0.0000 |
| Model 1 | 1.002 | 1.000 | −0.0002 | 0.0000 | 0.0000 | 0.0000 |
| Model 2 | 1.002 | 1.000 | −0.0001 | 0.0000 | 0.0000 | 0.0000 |
| Model 3 | 1.002 | 1.000 | −0.0001 | 0.0000 | 0.0000 | 0.0000 |
| C. rectus | ||||||
| Simple regression | 0.995 | 0.996 | −0.0014 | 0.0000 | −0.0002 | −0.0001 |
| Model 1 | 0.995 | 0.995 | −0.0012 | 0.0000 | −0.0002 | 0.0000 |
| Model 2 | 0.995 | 0.996 | −0.0010 | 0.0000 | −0.0002 | 0.0000 |
| Model 3 | 0.995 | 0.996 | −0.0011 | 0.0000 | −0.0002 | 0.0000 |
| E. corrodens | ||||||
| Simple regression | 0.999 | 1.000 | −0.0008 | 0.0000 | 0.0003 | 0.0001 |
| Model 1 | 0.999 | 1.000 | −0.0006 | 0.0000 | 0.0002 | 0.0001 |
| Model 2 | 0.999 | 1.000 | −0.0006 | 0.0000 | 0.0002 | 0.0001 |
| Model 3 | 0.999 | 1.000 | −0.0006 | 0.0000 | 0.0002 | 0.0001 |
| V. parvula | ||||||
| Simple regression | 1.000 | 0.997 | −0.0022 | 0.0000 | −0.0001 | 0.0001 |
| Model 1 | 1.000 | 0.997 | −0.0022 | 0.0000 | −0.0001 | 0.0001 |
| Model 2 | 1.000 | 0.997 | −0.0023 | 0.0000 | −0.0001 | 0.0001 |
| Model 3 | 1.000 | 0.997 | −0.0024 | 0.0000 | −0.0001 | 0.0001 |
| A. naeslundii | ||||||
| Simple regression | 1.000 | 1.000 | −0.0008 | 0.0000 | 0.0001 | 0.0000 |
| Model 1 | 1.000 | 1.000 | −0.0008 | 0.0000 | 0.0001 | 0.0000 |
| Model 2 | 1.000 | 1.000 | −0.0007 | 0.0000 | 0.0001 | 0.0000 |
| Model 3 | 1.000 | 1.000 | −0.0007 | 0.0000 | 0.0001 | 0.0000 |
Note: Values represent odds ratios for cerebral microbleeds and infarcts, and regression coefficients for all other continuous variables (regression coefficients of <0.0001 are reported as 0.0000).
Values are highlighted in color, if statistically significant. Model structure, colors, and shades as described in Table 2.