TABLE 6.

Findings from regression analyses utilizing infection ratio (the ratio of serum IgG response to each the 11 bacterial species assessed through checkerboard immunoblotting over the mean colonization by the homologous species assessed through checkerboard DNA‐DNA hybridization) as exposures and MRI features as outcomes

Infection ratio	Cerebral microbleeds	Infarcts	White matter hyperintensity volume	Hippocampal volume	Entorhinal cortex volume	AD signature
P. gingivalis
Simple regression	1.000	0.995	0.0008	0.00000018	0.000272	0.000044
Model 1	0.999	0.995	0.0004	0.00000027	0.000313	0.000089
Model 2	0.999	0.994	0.0003	0.00000026	0.000333	0.000101
Model 3	0.999	0.994	0.0002	0.00000027	0.000336	0.000103
P. intermedia
Simple regression	0.992	1.003	0.0018	0.00000221	0.000419	0.000193
Model 1	0.993	1.005	0.0026	0.00000204	−0.000004	0.000056
Model 2	0.993	1.005	0.0028	0.00000205	−0.000040	0.000030
Model 3	0.993	1.005	0.0028	0.00000204	−0.000046	0.000026
T. forsythia
Simple regression	0.997	1.000	−0.0004	0.00000044	0.000120	0.000011
Model 1	0.997	1.000	−0.0004	0.00000038	0.000135	0.000018
Model 2	0.997	1.000	−0.0004	0.00000038	0.000130	0.000016
Model 3	0.997	1.000	−0.0004	0.00000038	0.000132	0.000017
A. actinomycetemcomitans
Simple regression	1.000	1.000	−0.0002	0.00000008	0.000010	−0.000011
Model 1	1.000	1.000	−0.0001	0.00000003	−0.000040	−0.000033
Model 2	1.000	1.000	−0.0001	0.00000004	−0.000032	−0.000029
Model 3	1.000	1.000	−0.0001	0.00000004	−0.000032	−0.000029
F. nucleatum
Simple regression	1.058	0.994	0.0145	−0.00000018	−0.004770	−0.000455
Model 1	1.086	0.998	0.0179	0.00000030	−0.009970	−0.001470
Model 2	1.088	1.001	0.0207	0.00000088	−0.010300	−0.001560
Model 3	1.089	1.002	0.0206	0.00000092	−0.010300	−0.001550
T. denticola
Simple regression	1.002	0.999	−0.0034	−0.00000005	0.000664	0.000194
Model 1	1.000	1.000	−0.0037	0.00000028	0.000803	0.000231
Model 2	1.000	0.999	−0.0041	0.00000030	0.000792	0.000237
Model 3	1.000	0.999	−0.0041	0.00000028	0.000786	0.000233
M. micros
Simple regression	0.895	0.995	−0.0008	−0.00000028	0.000420	0.000167
Model 1	0.962	0.996	0.0003	−0.00000042	−0.000017	−0.000017
Model 2	0.961	0.997	0.0007	−0.00000039	−0.000102	−0.000069
Model 3	0.960	0.997	0.0007	−0.00000038	−0.000096	−0.000066
C. rectus
Simple regression	1.000	1.000	0.0000	0.00000004	0.000001	−0.000009
Model 1	1.000	1.000	0.0000	0.00000005	−0.000016	−0.000013
Model 2	1.000	1.000	0.0001	0.00000005	−0.000016	−0.000013
Model 3	1.000	1.000	0.0001	0.00000005	−0.000016	−0.000013
E. corrodens
Simple regression	1.003	0.998	−0.0005	0.00000046	−0.000470	0.000099
Model 1	1.002	0.998	−0.0005	0.00000036	−0.000472	0.000106
Model 2	1.002	0.998	−0.0005	0.00000036	−0.000469	0.000111
Model 3	1.002	0.998	−0.0005	0.00000036	−0.000470	0.000110
V. parvula
Simple regression	1.000	0.999	−0.0002	−0.00000005	0.000170	0.000091
Model 1	1.001	1.000	0.0002	−0.00000019	0.000067	0.000038
Model 2	1.001	1.000	0.0004	−0.00000019	0.000040	0.000020
Model 3	1.001	1.000	0.0004	−0.00000018	0.000045	0.000023
A. naeslundii
Simple regression	0.997	0.999	0.0002	−0.00000014	0.000031	0.000095
Model 1	0.998	0.999	0.0011	−0.00000023	−0.000176	−0.000019
Model 2	0.998	0.999	0.0012	−0.00000023	−0.000193	−0.000031
Model 3	0.998	0.999	0.0013	−0.00000024	−0.000197	−0.000033

Note: Values represent odds ratios for cerebral microbleeds and infarcts, and regression coefficients for all other continuous variables.

Values are highlighted in color, if statistically significant. Model structure, colors, and shades as described in Table 2.

Abbreviations: AD, Alzheimer's disease; IgG, immunoglobulin G; MRI, magnetic resonance imaging.