TABLE 3.
Association between multimorbidity and brain volumes at baseline and over time.
| TBTV β (95% CI) | HV β (95% CI) | Ventricular volume β (95% CI) | WMH volume β (95% CI) | |
|---|---|---|---|---|
| Multimorbidity (baseline) | ||||
| No multimorbidity | Ref. | Ref. | Ref. | Ref. |
| Multimorbidity | −0.33 (−0.51, −0.14) | −0.15 (−0.36, 0.07) | 0.27 (0.03, 0.51) | 0.12 (−0.14, 0.38) |
| Multimorbidity (× time) | ||||
| No multimorbidity | Ref. | Ref. | Ref. | Ref. |
| Multimorbidity | −0.03 (−0.05, −0.01) | −0.04 (−0.07, −0.01) | 0.02 (0.01, 0.04) | 0.03 (0.01, 0.06) |
| Number of chronic diseases (baseline) | −0.06 (−0.10, −0.02) | −0.06 (−0.10, −0.01) | 0.07 (0.02, 0.12) | 0.05 (−0.01, 0.11) |
| Number of chronic diseases (× time) | −0.01 (−0.01, 0.00) | −0.01 (−0.01, 0.00) | 0.01 (0.00, 0.01) | 0.01 (0.00, 0.01) |
Note: Coefficients are derived from linear mixed models and are adjusted for age, sex, education and APOE genotype. All volumes are adjusted for total intracranial volume and converted into z‐scores.
Abbreviations: CI: confidence interval; HV, hippocampal volume; TBTV: total brain tissue volume; WMH: white matter hyperintensities.