TABLE 1.
Demographic and clinical characteristics.
| NPDPSC | NACC | ||||
|---|---|---|---|---|---|
| Pathology‐confirmed rpAD | Normal controls | tAD | Clinical rpAD | ||
| n = 115 | n = 2213 | n = 525 | n = 193 | P | |
| Male (%) | 57 (49.6) | 700 (31.6) | 234 (44.6) | 79 (40.9) | <0.001 |
| Race (%) | <0.001 * | ||||
| Non‐Hispanic European | 92 (80.0) | 1522 (68.8) | 412 (78.5) | 133 (69.3) | |
| African American | 2 (1.7) | 686 (31.0) | 112 (21.3) | 52 (27.1) | |
| Asian | 0 (0.0) | 2 (0.1) | 1 (0.2) | 6 (3.1) | |
| American Indian/Alaska Native | 0 (0.0) | 3 (0.1) | 0 (0.0) | 0 (0.0) | |
| Other | 2 (1.7) | 0 (0.0) | 0 (0.0) | 1 (0.5) | |
| Unknown | 17 (14.8) | 0 (0.0) | 0 (0.0) | 0 (0.0) | |
| Hispanic (%) | 2 (1.7) | 24 (1.1) | 9 (1.7) | 5 (2.6) | 0.159 * |
| Years of education, mean (SD) | – | 15.8 (3.0) | 15.4 (3.0) | 14.5 (3.4) | <0.001 |
| Age of onset, mean (SD) | |||||
| Not deceased | – | – | 73.7 (11.1) | 69.3 (11.6) | <0.001 |
| Deceased | 71.0 (10.8) | – | 76.9 (8.8) | 80.7 (11.6) | <0.001 |
| Age at death, mean (SD) | 72.4 (10.1) | 84.3 (7.4) | 87.5 (8.3) | 83.2 (11.4) | <0.001 |
| Survival in years, median [IQR] ** | 0.6 [0.17–1.4] | – | 10.0 [8.0–13.0] | 3.0 [2.0–3.0] | <0.001 |
Abbreviations: IQR, interquartile range; NACC, National Alzheimer's Coordinating Center; NPDPSC, National Prion Disease Pathology Surveillance Center; rpAD, rapidly progressive Alzheimer's disease; SD, standard deviation; tAD, typical Alzheimer's disease.
*
P value was obtained from the Fishes exact test.
**
In NACC, survival was defined as the disease duration from the onset of symptoms until death.