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. 2023 Dec 13;20(3):1703–1715. doi: 10.1002/alz.13537

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© 2023 The Authors. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Distribution of genetic scores of AD along the AD continuum stratified by risk factors. (A) Distribution stratified by APOE‐ε4 carriership. (B) Distribution stratified by AT group. (C) Distribution stratified by sex. Pairwise comparisons are assessed to compare the median PRS‐AD (Wilcoxon test) among groups. Significant results at nominal p‐value are displayed (p‐value < 0.05^*; p‐value < 0.01^**, p‐value < 0.001^***). AD, Alzheimer's disease; APOE, apolipoprotein E; PRS‐AD, polygenic risk scores of AD.