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. 2023 Dec 18;20(3):1771–1783. doi: 10.1002/alz.13551

TABLE 2.

Voxel‐based morphometry results of significant cerebellar gray matter density decrease between patient groups and controls.

Cluster size MNI coordinates
Contrast (voxels) x y z T value Hemisphere Regions
TDP‐A < Controls 13225 −54 −53 −32 3.664 Bilateral Left Crus I extending into bilateral lobules I‐VI, Crus I, Crus II
Vermis
3623 −5 −57 −65 3.664 Bilateral Left lobule IX extending into bilateral VIIB, VIIIa, VIIIb, IX, X
Vermis
TDP‐B < Controls 514 −44 −41 −45 3.458 Left Left Crus II extending into lobule VI, Crus I, lobules VIIb, VIIIa
395 38 −39 −47 3.458 Right Lobule VIIIa extending into Crus I, Crus II, lobule VIIb, VIIIb
207 −8 −56 −3 3.334 Left Lobule V extending into lobule I–IV
137 47 −45 −29 2.470 Right Crus I extending into lobules V, VI
TDP‐C < Controls 1240 21 −89 −27 3.658 Right Crus I extending into lobule VI, Crus II
743 −41 −39 −32 3.658 Left Lobule VI extending into lobules I–V, Crus I
566 −33 −83 −36 2.841 Left Crus I extending into lobule VI, Crus II
Vermis
459 44 −38 −33 3.658 Right Lobule VI extending into lobules I–V, Crus I
Pick's < Controls 3373 45 −39 −32 3.659 Bilateral Right Crus I extending into bilateral Crus I, Crus II, right lobules V, VI, VIIb, VIIIa
Vermis
740 −50 −45 −33 3.659 Left Crus I extending into lobules V, VI
170 −3 −62 −3 3.170 Bilateral Left lobule V extending into bilateral lobules V and left lobules I–IV
125 −38 −78 −24 2.297 Left Crus I
CBD < Controls 920 −2 −75 −14 3.081 Bilateral Vermis extending into bilateral lobules V, VI, left lobules I–IV, right Crus I
Vermis
PSP < Controls 1325 12 −68 −12 3.447 Bilateral Right lobule VI extending into bilateral lobules I–VI
Vermis
183 −36 −78 −23 2.486 Left Crus I extending into Crus II
117 −39 −48 −27 2.507 Left Lobule VI extending into Crus I
112 14 −83 −20 2.380 Right Crus I extending into lobule VI
AD < Controls 10154 −26 −41 −57 3.618 Bilateral Left VIIIb extending into bilateral lobules I–VI, Crus I, Crus II, left lobules VIIIa, VIIIb, IX, X
Vermis
887 0 −57 −60 3.212 Bilateral Right lobule IX extending into bilateral lobules VIIb, VIIIa, IX, right lobule VIIIb
Vermis
144 −5 −47 −33 3.037 Bilateral Vermis extending into bilateral lobules IX
Vermis
139 24 −36 −52.5 2.823 Right Lobule VIIIb extending into lobule X
LBD‐AD < Controls 9612 3 −75 −47 3.620 Bilateral Right lobule VIIb extending into bilateral lobules I–VI, Crus I, Crus II, VIIb, VIIIa, VIIIb, right lobules IX, X
Vermis
609 0 −48 −45 2.995 Bilateral Right lobule IX extending into left lobule IX
Vermis
513 −29 −39 −56 3.620 Left Lobule VIIIb extending into lobules VIIIa, X

Note: Clusters were thresholded at p < 0.05 corrected for family‐wise error with a cluster extent threshold of 100 contiguous voxels.

Abbreviations: AD, Alzheimer's disease; CBD, corticobasal degeneration; LBD, Lewy body disease; PSP, progressive supranuclear palsy.