TABLE 2.
Voxel‐based morphometry results of significant cerebellar gray matter density decrease between patient groups and controls.
| Cluster size | MNI coordinates | ||||||
|---|---|---|---|---|---|---|---|
| Contrast | (voxels) | x | y | z | T value | Hemisphere | Regions |
| TDP‐A < Controls | 13225 | −54 | −53 | −32 | 3.664 | Bilateral | Left Crus I extending into bilateral lobules I‐VI, Crus I, Crus II |
| Vermis | |||||||
| 3623 | −5 | −57 | −65 | 3.664 | Bilateral | Left lobule IX extending into bilateral VIIB, VIIIa, VIIIb, IX, X | |
| Vermis | |||||||
| TDP‐B < Controls | 514 | −44 | −41 | −45 | 3.458 | Left | Left Crus II extending into lobule VI, Crus I, lobules VIIb, VIIIa |
| 395 | 38 | −39 | −47 | 3.458 | Right | Lobule VIIIa extending into Crus I, Crus II, lobule VIIb, VIIIb | |
| 207 | −8 | −56 | −3 | 3.334 | Left | Lobule V extending into lobule I–IV | |
| 137 | 47 | −45 | −29 | 2.470 | Right | Crus I extending into lobules V, VI | |
| TDP‐C < Controls | 1240 | 21 | −89 | −27 | 3.658 | Right | Crus I extending into lobule VI, Crus II |
| 743 | −41 | −39 | −32 | 3.658 | Left | Lobule VI extending into lobules I–V, Crus I | |
| 566 | −33 | −83 | −36 | 2.841 | Left | Crus I extending into lobule VI, Crus II | |
| Vermis | |||||||
| 459 | 44 | −38 | −33 | 3.658 | Right | Lobule VI extending into lobules I–V, Crus I | |
| Pick's < Controls | 3373 | 45 | −39 | −32 | 3.659 | Bilateral | Right Crus I extending into bilateral Crus I, Crus II, right lobules V, VI, VIIb, VIIIa |
| Vermis | |||||||
| 740 | −50 | −45 | −33 | 3.659 | Left | Crus I extending into lobules V, VI | |
| 170 | −3 | −62 | −3 | 3.170 | Bilateral | Left lobule V extending into bilateral lobules V and left lobules I–IV | |
| 125 | −38 | −78 | −24 | 2.297 | Left | Crus I | |
| CBD < Controls | 920 | −2 | −75 | −14 | 3.081 | Bilateral | Vermis extending into bilateral lobules V, VI, left lobules I–IV, right Crus I |
| Vermis | |||||||
| PSP < Controls | 1325 | 12 | −68 | −12 | 3.447 | Bilateral | Right lobule VI extending into bilateral lobules I–VI |
| Vermis | |||||||
| 183 | −36 | −78 | −23 | 2.486 | Left | Crus I extending into Crus II | |
| 117 | −39 | −48 | −27 | 2.507 | Left | Lobule VI extending into Crus I | |
| 112 | 14 | −83 | −20 | 2.380 | Right | Crus I extending into lobule VI | |
| AD < Controls | 10154 | −26 | −41 | −57 | 3.618 | Bilateral | Left VIIIb extending into bilateral lobules I–VI, Crus I, Crus II, left lobules VIIIa, VIIIb, IX, X |
| Vermis | |||||||
| 887 | 0 | −57 | −60 | 3.212 | Bilateral | Right lobule IX extending into bilateral lobules VIIb, VIIIa, IX, right lobule VIIIb | |
| Vermis | |||||||
| 144 | −5 | −47 | −33 | 3.037 | Bilateral | Vermis extending into bilateral lobules IX | |
| Vermis | |||||||
| 139 | 24 | −36 | −52.5 | 2.823 | Right | Lobule VIIIb extending into lobule X | |
| LBD‐AD < Controls | 9612 | 3 | −75 | −47 | 3.620 | Bilateral | Right lobule VIIb extending into bilateral lobules I–VI, Crus I, Crus II, VIIb, VIIIa, VIIIb, right lobules IX, X |
| Vermis | |||||||
| 609 | 0 | −48 | −45 | 2.995 | Bilateral | Right lobule IX extending into left lobule IX | |
| Vermis | |||||||
| 513 | −29 | −39 | −56 | 3.620 | Left | Lobule VIIIb extending into lobules VIIIa, X | |
Note: Clusters were thresholded at p < 0.05 corrected for family‐wise error with a cluster extent threshold of 100 contiguous voxels.
Abbreviations: AD, Alzheimer's disease; CBD, corticobasal degeneration; LBD, Lewy body disease; PSP, progressive supranuclear palsy.