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. Author manuscript; available in PMC: 2025 Jan 2.
Published in final edited form as: J Alzheimers Dis. 2024 Jan 2;97(1):327–343. doi: 10.3233/JAD-230619

Table 3.

Training results from the processing speed group. The tasks assessing processing speed are presented in italics and underlined. Baseline performance (BP) effects are first presented for the NIH Toolbox processing speed task: Pattern Comparison Processing Speed. Then, the effects of baseline performance on the task of interest (as indicated in the third column for each row) are presented.

Outcome type Test of interest Improvement from baseline Effect of BP on the PS Toolbox taska Effect of BP on the task of interest Effect of age
Train to task
Processing speed (N=11) p=0.00098, d=1.9** Pos, p=0.026, F(1,7)=4.33, R^2=0.55** Neg, p<0.001, F(1,8)=30.6, R^2=0.88** p=0.14, F(1,9) = 2.66, R^2=0.23
Inhibitory control (N=13) p=0.033, d=0.63** Neg, p=0.055, F(1,9)=2.45, R^2=0.35* p=0.12, F(1,10)=1.51, R^2=0.23 p=0.88, F(1,11) = 0.023, R^2=0.0021
Episodic memory (N=12) p=0.54, d=0.28 p=0.30, F(1,8)=0.66, R^2=0.14 Neg, p=0.030, F(1,9)=3.3, R^2=0.42** p=0.99, F(1,10) = 0.00026, R^2<0.0001
Working memory (N=10) p=0.86, d=−0.025 p=0.91, F(1,7)=0.78, R^2=0.18 p=0.28, F(1,7)=1.59, R^2=0.31 p=0.22, F(1,8) = 1.76, R^2=0.18
Cognitive flexibility (N=10) p=0.22, d=0.26 p=0.62, F(1,6)=0.30, R^2=0.091 p=0.18, F(1,7)=1.12, R^2=0.24 p=0.93, F(1,8)=0.0089, R^2=0.0011
NIH Toolbox
Fluid cognition composite (N=12) p=0.023, d=0.84** p=0.57, F(1,9)=0.82, R^2=0.16 p=0.13, F(1,9)=2.23, R^2=0.33 p=0.27, F(1,12)=1.40, R^2=0.12
Total cognition composite (N=12) p=0.057, d=0.69* p=0.46, F(1,9)= 3.22, R^2=0.42 p=0.35, F(1,9)=3.52, R^2=0.44 Pos, p=0.033, F(1,10)=6.10, R^2=0.38**
Crystalized cognition composite (N=12) p=0.21, d=0.32 p=0.52, F(1,9)=0.43, R^2=0.088 p=0.23, F(1,9)=1.06, R^2=0.19 p=0.52, F(1,10)=0.52, R^2=0.042
Pattern comparison processing speed (N=12) p=0.0098, d=0.91** p=0.14, F(1,9)=1.33, R^2=0.23 -- p=0.93, F(1,10)=0.0086, R^2=0.0086
Flanker inhibition (N=12) p=0.002, d=1.4** p=0.35, F(1,9)=0.98, R^2=0.18 p=0.65, F(1,9)=0.57, R^2=0.11 p=0.34, F(1,10)=1.00, R^2=0.091
Dimensional change card sort (N=12) p=0.082, d=0.65* p=0.94, F(1,9)=0.31, R^2=0.065 Neg, p=0.025, F(1,9)=4.19, R^2=0.48** p=0.41, F(1,10)=0.73, R^2=0.068
List sorting working memory (N=12) p=0.32, d=0.36 p=0.49, F(1,9)=1.68, R^2=0.27 p=0.14, F(1,9)=3.01, R^2=0.40 p=0.11, F(1,10)=2.99, R^2=0.23
Picture sequence memory (N=12) p=0.69, d=−0.12 Neg, p=0.095, F(1,9)=2.55, R^2=0.36* Neg, p=0.040, F(1,9)=3.84, R^2=0.46** p=0.28, F(1,10)=1.30, R^2=0.12
Oral symbol digit (N=12) p=0.11, d=0.41 p=0.29, F(1,9)=0.22, R^2=0.28 Neg, p=0.022, F(1,9)=5.72, R^2=0.56** p=0.16, F(1,10)=2.26, R^2=0.19
Rey auditory learning (N=12) p=0.0093, d=1.1** p=0.27, F(1,9)=0.75, R^2=0.14 p=0.62, F(1,9)=0.19, R^2=0.04 p=0.73, F(1,10)=0.13, R^2=0.013

Neg = significant negative association; Pos = significant positive association. PS= processing speed.

a

Results include age and training duration covariates in the model.

**

p<0.05;

*

p<0.10.