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. Author manuscript; available in PMC: 2025 Jan 2.
Published in final edited form as: J Alzheimers Dis. 2024 Jan 2;97(1):327–343. doi: 10.3233/JAD-230619

Table 4.

Training results from the Inhibitory Control group. The tasks corresponding to the T2T inhibitory control training domain and NIH Toolbox inhibitory control are presented in italics and underlined. Baseline performance (BP) effects are first presented for the inhibitory control task from the NIH Toolbox: Flanker Inhibition. Then, the effects of baseline performance on the task of interest (as indicated in the second column for each row) are presented.

Outcome type Task of interest Improvement from baseline Effect of BP on the IC Toolbox taska Effect of BP on the task of interest taska Effect of age
Train to task
Processing speed (N=8) p=0.25, d=0.51 p=0.48, F(1,5)=0.29, R^2=0.11 Neg, p=0.040, F(1,5)=3.79, R^2=0.60** p=0.98, F(1,6)=0.00059, R^2<0.0001
Inhibitory control (N=6) p=0.094, d=1.0* p=0.16, F(1,3)=1.79, R^2=0.54 Neg, p=0.059, F(1,3)=4.57, R^2=0.75* p=0.79, F(1,4)=0.083, R^2=0.020
Episodic memory (N=7) p=0.16, d=−0.52 p=0.57, F(1,4)=0.42, R^2=0.17 p=0.13, F(1,4)=2.18, R^2=0.52 p=0.51, F(1,5)=0.51, R^2=0.09
Working memory (N=7) p=0.3, d=0.47 p=0.77, F(1,4)=1.25, R^2=0.39 p=0.37, F(1,4)=2.0, R^2=0.50 p=0.15, R^2=0.27, F(1,5) = 2.94
Cognitive flexibility (N=5) p=0.13, d=0.96 Neg, p=0.0018, F(1,2)=295, R^2=0.997** p=0.84, F(1,2)=0.072, R^2=0.067 p=0.74, F(1,3)=0.13, R^2=0.042
NIH Toolbox
Fluid cogntion composite (N=8) p=0.031, d=0.85** Neg, p=0.068, F(1,5)=3.28, R^2=0.57* Neg, p=0.010, F(1,5)=2.56, R^2=0.51** p=0.44, F(1,6)=0.69, R^2=0.10
Total cognition composite (N=7) p=0.031, d=0.95** p=0.24, F(1,4)=2.37, R^2=0.54 p=0.11, F(1,4)=4.19, R^2=0.68 p=0.18, F(1,5)=2.41, R^2=0.33
Crystalized cognition composite (N=7) p=0.19, d=0.64 p=0.40, F(1,4)=0.077, R^2=0.72 Neg, p=0.090, F(1,4)=11.2, R^2=0.85* Pos, p=0.026, F(1,5)=9.76, R^2=0.66**
Pattern comparison processing speed (N=9) p=0.063, d=0.74* p=0.78, F(1,6)=1.18, R^2=0.28 Neg, p=0.040, F(1,6)=5.85, R^2=0.66** p=0.15, R^2=0.27, F(1,7)=2.63
Flanker inhibition (N=9) p=0.13, d=0.63 Neg, p<0.001, F(1,6)=29.2, R^2=0.91** -- p=0.22, F(1,7)=1.83, R^2=0.21
Dimensional change card sort (N=9) p=0.29, d=0.42 p=0.27, F(1,6)=1.1, R^2=0.27 Neg, p=0.027, F(1,6)=4.99, R^2=0.63** p=0.43, F(1,7)=0.70, R^2=0.091
List sorting working memory (N=8) p=0.92, d=0.11 p=0.19, F(1,5)=1.27, R^2=0.34 Neg, p=0.021, F(1,5)=5.80, R^2=0.70** p=0.69, F(1,6)=0.17, R^2=0.028
Picture sequence memory (N=9) p=0.098, d=0.68* p=0.14, F(1,6)=3.03, R^2=0.50 p=0.74, F(1,6)=1.12, R^2=0.27 p=0.16, F(1,7)=2.42, R^2=0.26
Oral symbol digit (N=8) p=0.055, d=0.62* p=0.48, F(1,5)=0.29, R^2=0.11 Neg, p=0.054, F(1,5)=3.15, R^2=0.56* p=0.995, F(1,6)<0.0001, R^2<0.0001
Rey auditory learning (N=7) p=0.95, d=0.12 Neg, p=0.092, F(1,4)=8.9, R^2=0.82* Pos, p=0.056, F(1,4)=11.6, R^2=0.85* Pos, p=0.043, F(1,5) =7.26, R^2=0.59**

Neg = significant negative association; Pos = significant positive association. IC = inhibitory control.

a

Results include age and cognitive domain covariates in the model.

**

p<0.05;

*

p<0.10.