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. Author manuscript; available in PMC: 2025 Jan 2.
Published in final edited form as: J Alzheimers Dis. 2024 Jan 2;97(1):327–343. doi: 10.3233/JAD-230619

Table 5.

Training results from the Episodic Memory group. The tasks corresponding to the T2T episodic memory training domain and NIH Toolbox inhibitory control are presented in italics and underlined. Baseline performance (BP) effects are first presented for the inhibitory control task from the NIH Toolbox: Picture sequence memory. Then, the effects of baseline performance on the task of interest (as indicated in the second column for each row) are presented.

Outcome type Task of interest Improvement from baseline Effect of BP on the EM Toolbox task* Effect of BP on the task of interest taska Effect of age
Train to task
Processing speed (N=6) p=0.69, d=−0.12 p=0.26, F(1,3) =0.99, R^2=0.40 Neg, p=0.098, F(1,3)=2.91, R^2=0.66* p=0.80, R^2=0.018, F(1,4) = 0.074
Inhibitory control (N=7) p=0.81, d=0.21 p=0.93, F(1,4)=2.10, R^2=0.51 Neg, p<0.001, F(1,4) = 134, R^2=0.99** Neg, p=0.071, F(1,5) = 5.22, R^2 = 0.51*
Episodic memory (N=7) p=0.031, d=1.1** p=0.58, F(1,4)=3.49, R^2=0.64 Neg, p=0.045, F(1,4)=4.15, R^2=0.68** p=0.96, R^2=0.00061, F(1,5) = 0.0030
Working memory (N=7) p=0.063, d=−1.11* p=0.62, F(1,4)=0.32, R2=0.14 Neg, p=0.020, F(1,4)=7.86, R^2=0.80** p=0.56, F(1,5) = 0.39, R^2=0.073
Cognitive flexibility (N=7) p=0.16, d=0.6 p=0.84, F(1,4)=0.054, R2=0.026 p=0.54, F(1,4)=0.26, R^2=0.11 p=0.80, F(1,5) = 0.072, R^2=0.014
NIH Toolbox
Fluid cogntion composite (N=8) p=0.047, d=0.99** p=0.84, F(1,5)=0.53, R^2=0.18 Neg, p=0.10, F(1,5)=2.9, R^2=0.54 p=0.31, F(1,6) = 1.21, R^2 = 0.17
Total cognition composite (N=8) p=0.094, d=0.77* p=0.88, F(1,5)=0.14, R^2=0.053 p=0.78, F(1,5)=0.17, R^2=0.064 p=0.60, F(1,6)=0.60, R^2=0.048
Crystalized cognition composite (N=8) p=0.27, d=−0.33 p=0.83, F(1,5)=0.23, R^2=0.083 p=0.29, F(1,5)=0.97, R^2=0.28 p=0.52, F(1,6) = 0.52, R^2=0.074
Pattern comparison processing speed (N=8) p=0.078, d=0.88* p=0.74, F(1,5)=0.30, R^2=0.11 p=0.33, F(1,5)=0.86, R^2=0.26 p=0.49, F(1,6) = 0.55, R^2=0.084
Flanker inhibition (N=8) p=0.7, d=0.11 p=0.99, F(1,5)=2.50, R^2=0.50 Neg, p=0.016, F(1,5)=15.2, R^2=0.86** Neg, p=0.050, F(1,6) = 6.01, R^2=0.50*
Dimensional change card sort (N=8) p=0.23, d=0.47 p=0.21, R^2=0.68, F(1,5)=5.39 p=0.24, F(1,5)=5.02, R^2=0.67 Neg, p=0.035, F(1,6) = 7.34, R^2=0.55**
List sorting working memory (N=8) p=0.13, d=0.55 p=0.81, F(1,5)=0.041, R^2=0.016 Neg, p=0.0074, F(1,5)=9.47, R^2=0.79** p=0.89, R^2=0.0033, F(1,6) = 0.020
Picture sequence memory (N=8) p=0.078, d=0.99* p=0.13, F(1,5)=1.71, R^2=0.41 -- p=0.87, R^2=0.0046, F(1,6) = 0.028
Oral symbol digit (N=8) p=0.97, d=0.028 p=0.52, F(1,5)=0.67, R^2=0.21 p=0.15, F(1,5)=2.04, R^2=0.45 p=0.37, R^2=0.14, F(1,6) = 0.94
Rey auditory learning (N=8) p=0.22, d=0.51 p=0.53, F(1,5)=4.89, R^2=0.66 p=0.11, F(1,5)=9.3, R^2=0.79 Pos, p=0.019, R^2=0.63, F(1,6) = 10.3**

Neg = significant negative association; Pos = significant positive association. EM = episodic memory.

a

Results include age and cognitive domain covariates in the model.

**

p<0.05;

*

p<0.10.