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. 2023 Dec 7;7(12):e0337. doi: 10.1097/HC9.0000000000000337

FIGURE 3.

FIGURE 3

Functional restoration from ex vivo PD-1 blockade across patient cohorts with chronic hepatitis B. Functional restoration was calculated and tabulated per patient for (A) IFN-γ and (B) IL-2 responses. The dotted line represents 0%, while full black lines indicate means with SDs. Fractions beneath each cohort indicate the number of patients having a functional restoration percentage of ≥20% and considered treatment-responsive to ex vivo PD-1 blockade. Mann-Whitney tests were used to compare functional restoration between patient cohorts (A, B) (* p<0.05, ** p<0.01, *** p<0.001). Abbreviations: FC, functionally cured; FR, functional restoration; IA, immune-active; IC, inactive carrier; IFN-γ, interferon; IT, immunotolerant PD-1, programmed cell death protein 1.