TABLE 4.
Factors associated with HCC in persons with cirrhosis and diabetesa
| Predictor | SHR | 95% CI |
|---|---|---|
| Duration of diabetes | ||
| 10+ y before cirrhosis | Ref | — |
| 5–10 y before cirrhosis | 1.08 | 1.00–1.18 |
| 2–5 y before cirrhosis | 1.15 | 1.04–1.27 |
| 0–2 y before cirrhosis | 1.34 | 1.22–1.48 |
| Insulin exposure at baseline | ||
| No insulin exposure | Ref | — |
| 5+ y before cirrhosis | 0.83 | 0.73–0.94 |
| 2–5 y before cirrhosis | 0.90 | 0.79–1.02 |
| 0–2 y before cirrhosis | 0.83 | 0.75–1.04 |
| Percent of follow-up with HgbA1c > 7% (per 10% increase) | 1.03 | 1.02–1.04 |
Note: Missing data for covariables was present as follows: AUDIT-C n = 124, smoking status n = 592, BMI n = 77.
a
Model further adjusted for HCV treatment status, baseline CTP class, statin use, AUDIT-C, age, sex, race/ethnicity, BMI, and tobacco use.
Abbreviations: AUDIT-C, Alcohol Use Disorders Identification Test-Consumption; BMI, body mass index; CTP Child-Turcotte-Pugh; HgbA1c, hemoglobin A1c; SHR, subdistribution HR.