TABLE 5.
Risk of HCC in persons with cirrhosis and diabetes by time-updating blood glucose control state, total sample, and stratified by CTP class
| Main analysisa: Blood glucose control defined as HgbA1c < 7% | Sensitivity analysisa: Blood glucose control defined as HgbA1c < 8% | |||||
|---|---|---|---|---|---|---|
| SHR | 95% CI | SHR | 95% CI | |||
| Total Sample | Sustained BG control (≥2 y) | Ref | — | Sustained BG control (≥2 y) | Ref | — |
| Nonsustained BG control (0–2 y) | 2.34 | 2.21–2.48 | Nonsustained BG control (0–2 y) | 2.23 | 2.11–2.36 | |
| Uncontrolled BG | 1.80 | 1.70–1.91 | Uncontrolled BG | 2.43 | 2.28–2.58 | |
| CTP A | Sustained BG control (≥2 y) | Ref | — | Sustained BG control (≥2 y) | Ref | — |
| Nonsustained BG control (0–2 y) | 2.40 | 2.24–2.56 | Nonsustained BG control (0–2 y) | 2.31 | 2.17–2.47 | |
| Uncontrolled BG | 1.76 | 1.65–1.88 | Uncontrolled BG | 2.41 | 2.25–2.59 | |
| CTP B | Sustained BG control (≥2 y) | Ref | — | Sustained BG control (≥2 y) | Ref | — |
| Nonsustained BG control (0–2 y) | 2.27 | 2.00–2.57 | Nonsustained BG control (0–2 y) | 2.06 | 1.83–2.33 | |
| Uncontrolled BG | 2.00 | 1.76–2.28 | Uncontrolled BG | 2.60 | 2.27–2.99 | |
| CTP C | Sustained BG control (≥2 y) | Ref | — | Sustained BG control (≥2 y) | Ref | — |
| Nonsustained BG control (0–2 y) | 1.75 | 1.25–2.45 | Nonsustained BG control (0–2 y) | 1.95 | 1.42–2.69 | |
| Uncontrolled BG | 1.93 | 1.28–2.92 | Uncontrolled BG | 3.04 | 1.94–4.76 | |
a
Models adjusted for time-updating CTP class except where stratified by CTP class matched to the time period of blood glucose control status, baseline statin use, HCV treatment status, AUDIT-C, age, sex, race/ethnicity, BMI, tobacco use.
Abbreviations: AUDIT-C, Alcohol Use Disorders Identification Test-Consumption; BG, blood glucose; BMI, body mass index; CTP Child-Turcotte-Pugh; HgbA1c, hemoglobin A1c; SHR, subdistribution HR.