TABLE 7.

Association between 1% change in protein intake and changes in liver histologic features over time

	ORADJ (95% CI)/% increase in protein	p	AUROCb (95% CI)
Histologic improvementc	1.02 (0.91–1.13)	0.74	0.69 (0.57–0.80)
Resolution of MASH	1.14 (0.99–1.31)	0.07	0.72 (0.57–0.86)
≥ 1 point improvement
NAS	0.97 (0.87–1.09)	0.60	0.78 (0.69–0.88)
Fibrosis	0.98 (0.86–1.13)	0.78	0.80 (0.71–0.89)
Ballooning	1.10 (0.90–1.33)	0.35	0.94 (0.90–0.99)
Lobular inflammation	1.05 (0.90–1.21)	0.55	0.89 (0.82–0.96)
Portal inflammation	0.99 (0.86–1.13)	0.83	0.79 (0.67–0.91)
Steatosis	1.03 (0.98–1.08)	0.22	0.77 (0.66–0.88)

Note: N = 87.

^avORADJ (95% CI)/% increase in protein.

^bArea under the receiver operating characteristic curves for the adjusted model.

^cHistological improvement is defined as a decrease in NAS to a score of 2 points or less and no worsening of fibrosis.

Abbreviation: AUROC, area under the receiver operating characteristic curve; NAS, nonalcoholic fatty liver disease activity score.